Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation
Language
en
Article de revue
This item was published in
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2016, vol. 373, p. 126 - 139
Elsevier
English Abstract
Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due totheir ability to increase energy deposition and subsequent direct damage to cells and DNA within theirlocal vicinity. ...Read more >
Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due totheir ability to increase energy deposition and subsequent direct damage to cells and DNA within theirlocal vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemicalyields. In this work we present, for the first time, an in silico investigation, based on the general purposeMonte Carlo simulation toolkit Geant4, into energy deposition and radical species production around aspherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed forincident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy.Read less <
English Keywords
Geant4-DNA
Nanoparticle
Radiolysis
Proton beam
Radiation therapy
Origin
Hal imported