Advances in element speciation analysis of biomedical samples using synchrotron-based techniques
Language
en
Article de revue
This item was published in
Trends in Analytical Chemistry. 2018, vol. 104, p. 22-41
Elsevier
English Abstract
Synchrotron-radiation X-ray absorption spectroscopy (XAS) is a direct method for speciation analysis with atomic resolution, providing information about the local chemical environment of the probed element. This article ...Read more >
Synchrotron-radiation X-ray absorption spectroscopy (XAS) is a direct method for speciation analysis with atomic resolution, providing information about the local chemical environment of the probed element. This article gives an overview of the basic principles of XAS and its application to element speciation in biomedical research. The basic principle and experimental modalities of XAS are introduced, followed by a discussion of both its limitations, such as beam damage or detection limits, and practical advices to improve experiments. An updated review of biomedical studies involving XAS published over the last 5 years is then provided, paying special attention to metal-based drug biotransformation, metal and nanoparticle toxicology, and element speciation in cancer, neurological, and general pathophysiology. Finally, trends and future developments such as hyphenated methods, in situ correlative imaging and speciation, in vivo X-ray Absorption Near Edge Spectroscopy (XANES), full-field XANES, and X-ray Free Electron Laser (XFEL) XAS are presented.Read less <
English Keywords
cancer
XAS
speciation
synchrotron
EXAFS
metals
XANES
neuropathology
nanoparticles
XFEL
Origin
Hal imported