ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.
Langue
EN
Article de revue
Ce document a été publié dans
Behavioral Neuroscience. 2011-06-01, vol. 125, n° 3, p. 465-72
Résumé en anglais
Rho-kinase (ROCK) is a downstream effector of RhoA, which has been associated with growth cone collapse and retraction in neurons. ROCK inhibition has been shown to protect against ischemic damage, thereby improving ...Lire la suite >
Mots clés en anglais
Amides
Animals
Brain Ischemia
Cyclin-Dependent Kinase 5
DNA-Binding Proteins
Disease Models
Animal
Enzyme Inhibitors
Hippocampus
Injections
Intraventricular
Male
Maze Learning
Memory Disorders
Nerve Degeneration
Neuroprotective Agents
Phosphorylation
Pyridines
Rats
Rats
Wistar
Spatial Behavior
rho-Associated Kinases
tau Proteins