SHERWOOD, Mark W.; OLIET, Stéphane; PANATIER, Aude

doi:10.3390/ijms22147258

SHERWOOD, Mark W.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

OLIET, Stéphane

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

PANATIER, Aude
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

International journal of molecular sciences. 2021-07-06, vol. 22, n° 14

Résumé en anglais

Synaptic plasticity is an extensively studied cellular correlate of learning and memory in which NMDARs play a starring role. One of the most interesting features of NMDARs is their ability to act as a co-incident detector. It is unique amongst neurotransmitter receptors in this respect. Coincident detection is possible because the opening of NMDARs requires membrane depolarisation and the binding of glutamate. Opening of NMDARs also requires a co-agonist. Although the dynamic regulation of glutamate and membrane depolarization have been well studied in coincident detection, the role of the co-agonist site is unexplored. It turns out that non-neuronal glial cells, astrocytes, regulate co-agonist availability, giving them the ability to influence synaptic plasticity. The unique morphology and spatial arrangement of astrocytes at the synaptic level affords them the capacity to sample and integrate information originating from unrelated synapses, regardless of any pre-synaptic and post-synaptic commonality. As astrocytes are classically considered slow re-sponders, their influence at the synapse is widely recognized as modulatory. The aim herein is to reconsider the potential of astrocytes to participate directly in ongoing synaptic NMDAR activity and co-incident detection.< Réduire

Mots clés en anglais

Astrocyte

Coincident detection

D-serine

Gliotransmission

Glycine

Neuron

NMDAR

Synapse cluster

Trip-partite synapse

URI

https://oskar-bordeaux.fr/handle/20.500.12278/124322

DOI

http://dx.doi.org/10.3390/ijms22147258

Project ANR

Contribution des récepteurs IP3 et du réticulum endoplasmique à la signalisation Ca2+ dans les astrocytes - ANR-17-CE16-0002
Exploration fonctionnelle du domaine astrocytaire - ANR-16-CE16-0001

Unités de recherche

Neurocentre Magendie - U1215

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NMDARs, coincidence detectors of astrocytic and neuronal activities