MO, Ingrid Vikøren; SCHATZ, Christophe; CHRISTENSEN, Bjørn E.

doi:10.1016/j.carbpol.2021.118193

MO, Ingrid Vikøren
Norwegian University of Science and Technology [Trondheim] [NTNU]

SCHATZ, Christophe

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

CHRISTENSEN, Bjørn E.
Norwegian University of Science and Technology [Trondheim] [NTNU]

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Carbohydrate Polymers. 2021-05-13, vol. 267, p. 118193

Résumé en anglais

Most polysaccharides used in polysaccharide-based block copolymers are attached to the second block through the reducing end, due to the few and highly polysaccharide specific non-reducing end (NRE) functionalisation methods available. Chitin oligomers, prepared by nitrous acid degradation of chitosan (AnM) can, however, be selectively oxidised by periodate since they only possess a single vicinal diol in the NRE residue. Here, we show that both aldehydes formed after oxidation are highly reactive towards bifunctional oxyamines and hydrazide linkers. Sub-stochiometric amounts of linkers resulted in conjugation of AnM oligomers through both chain termini to yield a discrete distribution of ‘polymerised’ oligomers. Such chitin-based block polymers were, in contrast to chitins of the same chain lengths, water-soluble. Oxidised AnM oligomers, functionalised at both termini can also enable the preparation of more complex block polysaccharides such as ABA- or ABC-type.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/124316

DOI

http://dx.doi.org/10.1016/j.carbpol.2021.118193

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Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Functionalisation of the non-reducing end of chitin by selective periodate oxidation: A new approach to form complex block polysaccharides and water-soluble chitin-based block polymers

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