CASTELLANOS JANKIEWICZ, Ashley; GUZMAN-QUEVEDO, Omar; FENELON, Valerie S.; ZIZZARI, Philippe; QUARTA, Carmelo; BELLOCCHIO, Luigi; TAILLEUX, Anne; CHARTON, Julie; FERNANDOIS, Daniela; HENRICSSON, Marcus; PIVETEAU, Catherine; SIMON, Vincent; ALLARD, Camille; QUEMENER, Sandrine; GUINOT, Valentine; HENNUYER, Nathalie; PERINO, Alessia; DUVEAU, Alexia; MAITRE, Marlene; LESTE-LASSERRE, Thierry; CLARK, Samantha; DUPUY, Nathalie; CANNICH, Astrid; GONZALES, Delphine; DEPREZ, Benoit; MITHIEUX, Gilles; DOMBROWICZ, David; BACKHED, Fredrik; PREVOT, Vincent; MARSICANO, Giovanni; STAELS, Bart; SCHOONJANS, Kristina; COTA, Daniela

doi:10.1016/j.cmet.2021.04.009

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

GUZMAN-QUEVEDO, Omar
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

FENELON, Valerie S.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Ce document a été publié dans

Cell Metabolism. 2021-07-06, vol. 33, n° 7, p. 1483-1492.e10

Résumé en anglais

Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. Here we show that hypothalamic BA content is reduced in diet-induced obese mice. Central administration of BAs or a specific TGR5 agonist in these animals decreases body weight and fat mass by activating the sympathetic nervous system, thereby promoting negative energy balance. Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothalamus favors the development of obesity and worsens established obesity by blunting sympathetic activity. Lastly, hypothalamic TGR5 signaling is required for the anti-obesity action of dietary BA supplementation. Together, these findings identify hypothalamic TGR5 signaling as a key mediator of a top-down neural mechanism that counteracts diet-induced obesity.< Réduire

Mots clés en anglais

Bile acids

Body weight

Diet

Energy expenditure

Food intake

GPBAR1

Hypothalamus

Obesity

Sympathetic nervous system

TGR5

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https://oskar-bordeaux.fr/handle/20.500.12278/124292

DOI

http://dx.doi.org/10.1016/j.cmet.2021.04.009

Unités de recherche

Neurocentre Magendie - U1215

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Hypothalamic bile acid-TGR5 signaling protects from obesity

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Mots clés en anglais

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