KUMAR, Abhishek; MORALÈS, Olivier; MORDON, Serge; DELHEM, Nadira; BOLESLAWSKI, Emmanuel

doi:10.3390/cancers13205176

MORDON, Serge
Bioingénierie tissulaire [BIOTIS]

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Article de revue

Ce document a été publié dans

Cancers. 2021-10-15, vol. 13, n° 20

Résumé en anglais

Photodynamic Therapy (PDT) relies on local or systemic administration of a light-sensitive dye, called photosensitizer, to accumulate into the target site followed by excitation with light of appropriate wavelength and fluence. This photo-activated molecule reacts with the intracellular oxygen to induce selective cytotoxicity of targeted cells by the generation of reactive oxygen species. Hepatocellular carcinoma (HCC), one of the leading causes of cancer-associated mortality worldwide, has insufficient treatment options available. In this review, we discuss the mechanism and merits of PDT along with its recent developments as an anti-cancerous therapy. We also highlight the application of this novel therapy for diagnosis, visualization, and treatment of HCC. We examine the underlying challenges, some pre-clinical and clinical studies, and possibilities of future studies associated with PDT. Finally, we discuss the mechanism of an active immune response by PDT and thereafter explored the role of PDT in the generation of anti-tumor immune response in the context of HCC, with an emphasis on checkpoint inhibitor-based immunotherapy. The objective of this review is to propose PDT as a plausible adjuvant to existing therapies for HCC, highlighting a feasible combinatorial approach for HCC treatment.< Réduire

Mots clés en anglais

active targetin

anti-cancer therapy

anti-tumor immunity

cirrhosis

passive targeting

URI

https://oskar-bordeaux.fr/handle/20.500.12278/124237

DOI

http://dx.doi.org/10.3390/cancers13205176

Unités de recherche

Bioingénierie Tissulaire (BioTis) - U1026

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Could Photodynamic Therapy Be a Promising Therapeutic Modality in Hepatocellular Carcinoma Patients? A Critical Review of Experimental and Clinical Studies.

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Résumé en anglais

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