DAVIES, G.; LAM, M.; HARRIS, S. E.; TRAMPUSH, J. W.; LUCIANO, M.; HILL, W. D.; HAGENAARS, S. P.; RITCHIE, S. J.; MARIONI, R. E.; FAWNS-RITCHIE, C.; LIEWALD, D. C. M.; OKELY, J. A.; AHOLA-OLLI, A. V.; BARNES, C. L. K.; BERTRAM, L.; BIS, J. C.; BURDICK, K. E.; CHRISTOFOROU, A.; DEROSSE, P.; DJUROVIC, S.; ESPESETH, T.; GIAKOUMAKI, S.; GIDDALURU, S.; GUSTAVSON, D. E.; HAYWARD, C.; HOFER, E.; IKRAM, M. A.; KARLSSON, R.; KNOWLES, E.; LAHTI, J.; LEBER, M.; LI, S.; MATHER, K. A.; MELLE, I.; MORRIS, D.; OLDMEADOW, C.; PALVIAINEN, T.; PAYTON, A.; PAZOKI, R.; PETROVIC, K.; REYNOLDS, C. A.; SARGURUPREMRAJ, Muralidharan; SCHOLZ, M.; SMITH, J. A.; SMITH, A. V.; TERZIKHAN, N.; THALAMUTHU, A.; TROMPET, S.; VAN DER LEE, S. J.; WARE, E. B.; WINDHAM, B. G.; WRIGHT, M. J.; YANG, J.; YU, J.; AMES, D.; AMIN, N.; AMOUYEL, Philippe; ANDREASSEN, O. A.; ARMSTRONG, N. J.; ASSAREH, A. A.; ATTIA, J. R.; ATTIX, D.; AVRAMOPOULOS, D.; BENNETT, D. A.; BOHMER, A. C.; BOYLE, P. A.; BRODATY, H.; CAMPBELL, H.; CANNON, T. D.; CIRULLI, E. T.; CONGDON, E.; CONLEY, E. D.; CORLEY, J.; COX, S. R.; DALE, A. M.; DEHGHAN, A.; DICK, D.; DICKINSON, D.; ERIKSSON, J. G.; EVANGELOU, E.; FAUL, J. D.; FORD, I.; FREIMER, N. A.; GAO, H.; GIEGLING, I.; GILLESPIE, N. A.; GORDON, S. D.; GOTTESMAN, R. F.; GRISWOLD, M. E.; GUDNASON, V.; HARRIS, T. B.; HARTMANN, A. M.; HATZIMANOLIS, A.; HEISS, G.; HOLLIDAY, E. G.; JOSHI, P. K.; KAHONEN, M.; KARDIA, S. L. R.; KARLSSON, I.; KLEINEIDAM, L.; KNOPMAN, D. S.; KOCHAN, N. A.; KONTE, B.; KWOK, J. B.; LE HELLARD, S.; LEE, T.; LEHTIMAKI, T.; LI, S. C.; LIU, T.; KOINI, M.; LONDON, E.; LONGSTRETH, W. T., Jr.; LOPEZ, O. L.; LOUKOLA, A.; LUCK, T.; LUNDERVOLD, A. J.; LUNDQUIST, A.; LYYTIKAINEN, L. P.; MARTIN, N. G.; MONTGOMERY, G. W.; MURRAY, A. D.; NEED, A. C.; NOORDAM, R.; NYBERG, L.; OLLIER, W.; PAPENBERG, G.; PATTIE, A.; POLASEK, O.; POLDRACK, R. A.; PSATY, B. M.; REPPERMUND, S.; RIEDEL-HELLER, S. G.; ROSE, R. J.; ROTTER, J. I.; ROUSSOS, P.; ROVIO, S. P.; SABA, Y.; SABB, F. W.; SACHDEV, P. S.; SATIZABAL, C. L.; SCHMID, M.; SCOTT, R. J.; SCULT, M. A.; SIMINO, J.; SLAGBOOM, P. E.; SMYRNIS, N.; SOUMARE, Aicha; STEFANIS, N. C.; STOTT, D. J.; STRAUB, R. E.; SUNDET, K.; TAYLOR, A. M.; TAYLOR, K. D.; TZOULAKI, I.; TZOURIO, Christophe; UITTERLINDEN, A.; VITART, V.; VOINESKOS, A. N.; KAPRIO, J.; WAGNER, M.; WAGNER, H.; WEINHOLD, L.; WEN, K. H.; WIDEN, E.; YANG, Q.; ZHAO, W.; ADAMS, H. H. H.; ARKING, D. E.; BILDER, R. M.; BITSIOS, P.; BOERWINKLE, E.; CHIBA-FALEK, O.; CORVIN, A.; DE JAGER, P. L.; DEBETTE, Stephanie; DONOHOE, G.; ELLIOTT, P.; FITZPATRICK, A. L.; GILL, M.; GLAHN, D. C.; HAGG, S.; HANSELL, N. K.; HARIRI, A. R.; IKRAM, M. K.; JUKEMA, J. W.; VUOKSIMAA, E.; KELLER, M. C.; KREMEN, W. S.; LAUNER, L.; LINDENBERGER, U.; PALOTIE, A.; PEDERSEN, N. L.; PENDLETON, N.; PORTEOUS, D. J.; RAIKKONEN, K.; RAITAKARI, O. T.; RAMIREZ, A.; REINVANG, I.; RUDAN, I.; DAN, Rujescu; SCHMIDT, R.; SCHMIDT, H.; SCHOFIELD, P. W.; SCHOFIELD, P. R.; STARR, J. M.; STEEN, V. M.; TROLLOR, J. N.; TURNER, S. T.; VAN DUIJN, C. M.; VILLRINGER, A.; WEINBERGER, D. R.; WEIR, D. R.; WILSON, J. F.; MALHOTRA, A.; MCINTOSH, A. M.; GALE, C. R.; SESHADRI, Sudha; MOSLEY, T. H., Jr.; BRESSLER, J.; LENCZ, T.; DEARY, I. J.

doi:10.1038/s41467-018-04362-x

Langue

Article de revue

Ce document a été publié dans

Nature Communications. 2018-05-29, vol. 9, n° 1, p. 2098

Résumé en anglais

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.< Réduire

Mots clés en anglais

VINTAGE

URI

https://oskar-bordeaux.fr/handle/20.500.12278/11585

DOI

http://dx.doi.org/10.1038/s41467-018-04362-x

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche