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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

dc.rights.licenseopenen_US
dc.contributor.authorDAVIES, G.
dc.contributor.authorLAM, M.
dc.contributor.authorHARRIS, S. E.
dc.contributor.authorTRAMPUSH, J. W.
dc.contributor.authorLUCIANO, M.
dc.contributor.authorHILL, W. D.
dc.contributor.authorHAGENAARS, S. P.
dc.contributor.authorRITCHIE, S. J.
dc.contributor.authorMARIONI, R. E.
dc.contributor.authorFAWNS-RITCHIE, C.
dc.contributor.authorLIEWALD, D. C. M.
dc.contributor.authorOKELY, J. A.
dc.contributor.authorAHOLA-OLLI, A. V.
dc.contributor.authorBARNES, C. L. K.
dc.contributor.authorBERTRAM, L.
dc.contributor.authorBIS, J. C.
dc.contributor.authorBURDICK, K. E.
dc.contributor.authorCHRISTOFOROU, A.
dc.contributor.authorDEROSSE, P.
dc.contributor.authorDJUROVIC, S.
dc.contributor.authorESPESETH, T.
dc.contributor.authorGIAKOUMAKI, S.
dc.contributor.authorGIDDALURU, S.
dc.contributor.authorGUSTAVSON, D. E.
dc.contributor.authorHAYWARD, C.
dc.contributor.authorHOFER, E.
dc.contributor.authorIKRAM, M. A.
dc.contributor.authorKARLSSON, R.
dc.contributor.authorKNOWLES, E.
dc.contributor.authorLAHTI, J.
dc.contributor.authorLEBER, M.
dc.contributor.authorLI, S.
dc.contributor.authorMATHER, K. A.
dc.contributor.authorMELLE, I.
dc.contributor.authorMORRIS, D.
dc.contributor.authorOLDMEADOW, C.
dc.contributor.authorPALVIAINEN, T.
dc.contributor.authorPAYTON, A.
dc.contributor.authorPAZOKI, R.
dc.contributor.authorPETROVIC, K.
dc.contributor.authorREYNOLDS, C. A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSARGURUPREMRAJ, Muralidharan
dc.contributor.authorSCHOLZ, M.
dc.contributor.authorSMITH, J. A.
dc.contributor.authorSMITH, A. V.
dc.contributor.authorTERZIKHAN, N.
dc.contributor.authorTHALAMUTHU, A.
dc.contributor.authorTROMPET, S.
dc.contributor.authorVAN DER LEE, S. J.
dc.contributor.authorWARE, E. B.
dc.contributor.authorWINDHAM, B. G.
dc.contributor.authorWRIGHT, M. J.
dc.contributor.authorYANG, J.
dc.contributor.authorYU, J.
dc.contributor.authorAMES, D.
dc.contributor.authorAMIN, N.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorANDREASSEN, O. A.
dc.contributor.authorARMSTRONG, N. J.
dc.contributor.authorASSAREH, A. A.
dc.contributor.authorATTIA, J. R.
dc.contributor.authorATTIX, D.
dc.contributor.authorAVRAMOPOULOS, D.
dc.contributor.authorBENNETT, D. A.
dc.contributor.authorBOHMER, A. C.
dc.contributor.authorBOYLE, P. A.
dc.contributor.authorBRODATY, H.
dc.contributor.authorCAMPBELL, H.
dc.contributor.authorCANNON, T. D.
dc.contributor.authorCIRULLI, E. T.
dc.contributor.authorCONGDON, E.
dc.contributor.authorCONLEY, E. D.
dc.contributor.authorCORLEY, J.
dc.contributor.authorCOX, S. R.
dc.contributor.authorDALE, A. M.
dc.contributor.authorDEHGHAN, A.
dc.contributor.authorDICK, D.
dc.contributor.authorDICKINSON, D.
dc.contributor.authorERIKSSON, J. G.
dc.contributor.authorEVANGELOU, E.
dc.contributor.authorFAUL, J. D.
dc.contributor.authorFORD, I.
dc.contributor.authorFREIMER, N. A.
dc.contributor.authorGAO, H.
dc.contributor.authorGIEGLING, I.
dc.contributor.authorGILLESPIE, N. A.
dc.contributor.authorGORDON, S. D.
dc.contributor.authorGOTTESMAN, R. F.
dc.contributor.authorGRISWOLD, M. E.
dc.contributor.authorGUDNASON, V.
dc.contributor.authorHARRIS, T. B.
dc.contributor.authorHARTMANN, A. M.
dc.contributor.authorHATZIMANOLIS, A.
dc.contributor.authorHEISS, G.
dc.contributor.authorHOLLIDAY, E. G.
dc.contributor.authorJOSHI, P. K.
dc.contributor.authorKAHONEN, M.
dc.contributor.authorKARDIA, S. L. R.
dc.contributor.authorKARLSSON, I.
dc.contributor.authorKLEINEIDAM, L.
dc.contributor.authorKNOPMAN, D. S.
dc.contributor.authorKOCHAN, N. A.
dc.contributor.authorKONTE, B.
dc.contributor.authorKWOK, J. B.
dc.contributor.authorLE HELLARD, S.
dc.contributor.authorLEE, T.
dc.contributor.authorLEHTIMAKI, T.
dc.contributor.authorLI, S. C.
dc.contributor.authorLIU, T.
dc.contributor.authorKOINI, M.
dc.contributor.authorLONDON, E.
dc.contributor.authorLONGSTRETH, W. T., Jr.
dc.contributor.authorLOPEZ, O. L.
dc.contributor.authorLOUKOLA, A.
dc.contributor.authorLUCK, T.
dc.contributor.authorLUNDERVOLD, A. J.
dc.contributor.authorLUNDQUIST, A.
dc.contributor.authorLYYTIKAINEN, L. P.
dc.contributor.authorMARTIN, N. G.
dc.contributor.authorMONTGOMERY, G. W.
dc.contributor.authorMURRAY, A. D.
dc.contributor.authorNEED, A. C.
dc.contributor.authorNOORDAM, R.
dc.contributor.authorNYBERG, L.
dc.contributor.authorOLLIER, W.
dc.contributor.authorPAPENBERG, G.
dc.contributor.authorPATTIE, A.
dc.contributor.authorPOLASEK, O.
dc.contributor.authorPOLDRACK, R. A.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorREPPERMUND, S.
dc.contributor.authorRIEDEL-HELLER, S. G.
dc.contributor.authorROSE, R. J.
dc.contributor.authorROTTER, J. I.
dc.contributor.authorROUSSOS, P.
dc.contributor.authorROVIO, S. P.
dc.contributor.authorSABA, Y.
dc.contributor.authorSABB, F. W.
dc.contributor.authorSACHDEV, P. S.
dc.contributor.authorSATIZABAL, C. L.
dc.contributor.authorSCHMID, M.
dc.contributor.authorSCOTT, R. J.
dc.contributor.authorSCULT, M. A.
dc.contributor.authorSIMINO, J.
dc.contributor.authorSLAGBOOM, P. E.
dc.contributor.authorSMYRNIS, N.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSOUMARE, Aicha
dc.contributor.authorSTEFANIS, N. C.
dc.contributor.authorSTOTT, D. J.
dc.contributor.authorSTRAUB, R. E.
dc.contributor.authorSUNDET, K.
dc.contributor.authorTAYLOR, A. M.
dc.contributor.authorTAYLOR, K. D.
dc.contributor.authorTZOULAKI, I.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorUITTERLINDEN, A.
dc.contributor.authorVITART, V.
dc.contributor.authorVOINESKOS, A. N.
dc.contributor.authorKAPRIO, J.
dc.contributor.authorWAGNER, M.
dc.contributor.authorWAGNER, H.
dc.contributor.authorWEINHOLD, L.
dc.contributor.authorWEN, K. H.
dc.contributor.authorWIDEN, E.
dc.contributor.authorYANG, Q.
dc.contributor.authorZHAO, W.
dc.contributor.authorADAMS, H. H. H.
dc.contributor.authorARKING, D. E.
dc.contributor.authorBILDER, R. M.
dc.contributor.authorBITSIOS, P.
dc.contributor.authorBOERWINKLE, E.
dc.contributor.authorCHIBA-FALEK, O.
dc.contributor.authorCORVIN, A.
dc.contributor.authorDE JAGER, P. L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDONOHOE, G.
dc.contributor.authorELLIOTT, P.
dc.contributor.authorFITZPATRICK, A. L.
dc.contributor.authorGILL, M.
dc.contributor.authorGLAHN, D. C.
dc.contributor.authorHAGG, S.
dc.contributor.authorHANSELL, N. K.
dc.contributor.authorHARIRI, A. R.
dc.contributor.authorIKRAM, M. K.
dc.contributor.authorJUKEMA, J. W.
dc.contributor.authorVUOKSIMAA, E.
dc.contributor.authorKELLER, M. C.
dc.contributor.authorKREMEN, W. S.
dc.contributor.authorLAUNER, L.
dc.contributor.authorLINDENBERGER, U.
dc.contributor.authorPALOTIE, A.
dc.contributor.authorPEDERSEN, N. L.
dc.contributor.authorPENDLETON, N.
dc.contributor.authorPORTEOUS, D. J.
dc.contributor.authorRAIKKONEN, K.
dc.contributor.authorRAITAKARI, O. T.
dc.contributor.authorRAMIREZ, A.
dc.contributor.authorREINVANG, I.
dc.contributor.authorRUDAN, I.
dc.contributor.authorDAN, Rujescu
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorSCHMIDT, H.
dc.contributor.authorSCHOFIELD, P. W.
dc.contributor.authorSCHOFIELD, P. R.
dc.contributor.authorSTARR, J. M.
dc.contributor.authorSTEEN, V. M.
dc.contributor.authorTROLLOR, J. N.
dc.contributor.authorTURNER, S. T.
dc.contributor.authorVAN DUIJN, C. M.
dc.contributor.authorVILLRINGER, A.
dc.contributor.authorWEINBERGER, D. R.
dc.contributor.authorWEIR, D. R.
dc.contributor.authorWILSON, J. F.
dc.contributor.authorMALHOTRA, A.
dc.contributor.authorMCINTOSH, A. M.
dc.contributor.authorGALE, C. R.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorMOSLEY, T. H., Jr.
dc.contributor.authorBRESSLER, J.
dc.contributor.authorLENCZ, T.
dc.contributor.authorDEARY, I. J.
dc.date.accessioned2020-11-02T15:04:44Z
dc.date.available2020-11-02T15:04:44Z
dc.date.issued2018-05-29
dc.identifier.issn2041-1723 (Electronic) 2041-1723 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11585
dc.description.abstractEnGeneral cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enVINTAGE
dc.title.enStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
dc.title.alternativeNat Communen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-018-04362-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29844566en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page2098en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPH
bordeaux.teamVINTAGE
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03165449
hal.version1
hal.date.transferred2021-03-10T15:30:21Z
hal.exporttrue
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