Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2
dc.rights.license | open | en_US |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | HARLY, Christelle | |
dc.contributor.author | JOYCE, Stephen Paul | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | DOMBLIDES, Charlotte | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | BACHELET, Thomas | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | PITARD, Vincent | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | MANNAT, Charlotte | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | PAPPALARDO, Angela | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | COUZI, Lionel | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | NETZER, Sonia | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | MASSARA, Layal | |
hal.structure.identifier | Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB] | |
dc.contributor.author | OBRE, Emilie | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | HAWCHAR, Omar | |
hal.structure.identifier | Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION] | |
dc.contributor.author | LARTIGUE, Lydia | |
hal.structure.identifier | Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB] | |
dc.contributor.author | CLAVEROL, Stephane | |
dc.contributor.author | CANO, Carla | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | MOREAU, Jean-Francois | |
hal.structure.identifier | Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION] | |
dc.contributor.author | MAHOUCHE, Isabelle | |
hal.structure.identifier | Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION] | |
dc.contributor.author | SOUBEYRAN, Isabelle | |
hal.structure.identifier | Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB] | |
hal.structure.identifier | Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM] | |
dc.contributor.author | ROSSIGNOL, Rodrigue | |
dc.contributor.author | VIOLLET, Benoit | |
dc.contributor.author | WILLCOX, Carrie R. | |
dc.contributor.author | MOHAMMED, Fiyaz | |
dc.contributor.author | WILLCOX, Benjamin E. | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | FAUSTIN, Benjamin | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | DECHANET-MERVILLE, Julie
IDREF: 061667994 | |
dc.date.accessioned | 2021-10-26T09:40:15Z | |
dc.date.available | 2021-10-26T09:40:15Z | |
dc.date.issued | 2021-07-30 | |
dc.identifier.issn | 2470-9468 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112879 | |
dc.description.abstractEn | Human γδ T cells play a critical role in surveillance against infection and cancer and use various mechanisms to sense metabolic changes associated with these assaults. Harly et al. describe a role for the stress ligand ephrin type-A receptor 2 (EphA2), which is up-regulated on cancer cells and is recognized by the human Vγ9Vδ1 T cell receptor (TCR) together with ephrin A. EphA2 up-regulation was mediated by metabolic changes in cancer cells caused by AMP-activated protein kinase (AMPK) activity. Increased coexpression of EphA2 and AMPK in tumor tissues was also linked to greater T cell infiltration in human colorectal cancer tissue. These findings suggest that human γδ T cells can sense changes in stress ligands and trigger responses caused by metabolic changes associated with infection or cancer. | |
dc.language.iso | EN | en_US |
dc.title.en | Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2 | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1126/sciimmunol.aba9010 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
dc.identifier.pubmed | 34330813 | en_US |
bordeaux.journal | Science Immunology | en_US |
bordeaux.volume | 6 | en_US |
bordeaux.hal.laboratories | Maladies Rares : Génétique et Métabolisme (MRGM) - UMR 1211 | en_US |
bordeaux.issue | 61 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Immunology&rft.date=2021-07-30&rft.volume=6&rft.issue=61&rft.eissn=2470-9468&rft.issn=2470-9468&rft.au=HARLY,%20Christelle&JOYCE,%20Stephen%20Paul&DOMBLIDES,%20Charlotte&BACHELET,%20Thomas&PITARD,%20Vincent&rft.genre=article |
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