COLLET, Cyrielle; FAYON, Michael; FRANCIS-OLIVIERO, Florence; GALODE, Francois; BUI, Stephanie; DEBELLEIX, Stephane

doi:10.3390/healthcare9081089

FAYON, Michael
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]

FRANCIS-OLIVIERO, Florence

Bordeaux population health [BPH]

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Article de revue

Ce document a été publié dans

Healthcare. 2021-08-23, vol. 9, n° 8

Résumé en anglais

Preschool wheezing and related hospitalization rates are increasing. Prenatal tobacco smoke exposure (PTSE) increases the risk of wheezing, yet >20% of French women smoke during pregnancy. In this observational retrospective monocentric study, we assessed the link between PTSE and hospital admissions. We included infants <2 years of age admitted for acute wheezing. A phone interview with mothers was completed by electronic records. The primary endpoint was the ratio of cumulative duration of the hospitalization stays (days)/age (months). 129 children were included (36.4% exposed to PTSE vs. 63.6% unexposed). There was a significant difference in the duration of hospitalization/age: 0.9 days/month (exposed) vs. 0.58 days/month (unexposed) (p = 0.008). Smoking one cigarette/day during pregnancy was associated with an increase in hospitalization duration of 0.055 days/month (r = 0.238, p = 0.006). In the multi-variable analysis, this positive association persisted (β = 0.04, p = 0.04; standardized β = 0.27, p = 0.03). There was a trend towards a dose-effect relationship between PTSE and other important parameters associated with hospital admissions. We have demonstrated a dose-effect relationship, without a threshold effect, between PTSE and duration of hospitalization for wheezing in non-premature infants during the first 2 years of life. Prevention campaigns for future mothers should be enforced.< Réduire

Mots clés en anglais

Asthma

Child

Preschool

Prenatal exposure

Delayed effects

Pregnancy

Smoking

Adverse effect

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112510

DOI

http://dx.doi.org/10.3390/healthcare9081089

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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The First 1000 Days: Impact of Prenatal Tobacco Smoke Exposure on Hospitalization Due to Preschool Wheezing

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