The First 1000 Days: Impact of Prenatal Tobacco Smoke Exposure on Hospitalization Due to Preschool Wheezing
| dc.rights.license | open | en_US |
| dc.contributor.author | COLLET, Cyrielle | |
| hal.structure.identifier | Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB] | |
| dc.contributor.author | FAYON, Michael | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FRANCIS-OLIVIERO, Florence | |
| dc.contributor.author | GALODE, Francois | |
| hal.structure.identifier | Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB] | |
| dc.contributor.author | BUI, Stephanie | |
| hal.structure.identifier | Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB] | |
| dc.contributor.author | DEBELLEIX, Stephane | |
| dc.date.accessioned | 2021-10-01T09:36:04Z | |
| dc.date.available | 2021-10-01T09:36:04Z | |
| dc.date.issued | 2021-08-23 | |
| dc.identifier.issn | 2227-9032 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112510 | |
| dc.description.abstractEn | Preschool wheezing and related hospitalization rates are increasing. Prenatal tobacco smoke exposure (PTSE) increases the risk of wheezing, yet >20% of French women smoke during pregnancy. In this observational retrospective monocentric study, we assessed the link between PTSE and hospital admissions. We included infants <2 years of age admitted for acute wheezing. A phone interview with mothers was completed by electronic records. The primary endpoint was the ratio of cumulative duration of the hospitalization stays (days)/age (months). 129 children were included (36.4% exposed to PTSE vs. 63.6% unexposed). There was a significant difference in the duration of hospitalization/age: 0.9 days/month (exposed) vs. 0.58 days/month (unexposed) (p = 0.008). Smoking one cigarette/day during pregnancy was associated with an increase in hospitalization duration of 0.055 days/month (r = 0.238, p = 0.006). In the multi-variable analysis, this positive association persisted (β = 0.04, p = 0.04; standardized β = 0.27, p = 0.03). There was a trend towards a dose-effect relationship between PTSE and other important parameters associated with hospital admissions. We have demonstrated a dose-effect relationship, without a threshold effect, between PTSE and duration of hospitalization for wheezing in non-premature infants during the first 2 years of life. Prevention campaigns for future mothers should be enforced. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Asthma | |
| dc.subject.en | Child | |
| dc.subject.en | Preschool | |
| dc.subject.en | Prenatal exposure | |
| dc.subject.en | Delayed effects | |
| dc.subject.en | Pregnancy | |
| dc.subject.en | Smoking | |
| dc.subject.en | Adverse effect | |
| dc.title.en | The First 1000 Days: Impact of Prenatal Tobacco Smoke Exposure on Hospitalization Due to Preschool Wheezing | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/healthcare9081089 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34442226 | en_US |
| bordeaux.journal | Healthcare | en_US |
| bordeaux.volume | 9 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03361228 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-10-01T09:36:08Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Healthcare&rft.date=2021-08-23&rft.volume=9&rft.issue=8&rft.eissn=2227-9032&rft.issn=2227-9032&rft.au=COLLET,%20Cyrielle&FAYON,%20Michael&FRANCIS-OLIVIERO,%20Florence&GALODE,%20Francois&BUI,%20Stephanie&rft.genre=article |
