BUSQUETS-GARCIA, Arnau; SORIA-GOMEZ, Edgar; FERREIRA, Guillaume; MARSICANO, Giovanni

doi:10.21769/BioProtoc.2358

FERREIRA, Guillaume
Nutrition et Neurobiologie intégrée [NutriNeuro]

Langue

Article de revue

Ce document a été publié dans

Bio-protocol. 2017, vol. 7, n° 12, p. 1-11

Résumé en anglais

Several paradigms for rodent models of the cognitive and negative endophenotypes found in schizophrenic patients have been proposed. However, significant efforts are needed in order to study the pathophysiology of schizophrenia-related positive symptoms. Recently, it has been shown that these positive symptoms can be studied in rats by using representation-mediated learning. This learning measure the accuracy of mental representations of reality, also called 'reality testing'. Alterations in 'reality testing' performance can be an indication of an impairment in perception which is a clear hallmark of positive psychotic-like states. Thus, we describe here a mouse task adapted from previous findings based on a sensory preconditioning task. With this task, associations made between different neutral stimuli (e.g., an odor and a taste) and subsequent selective devaluation of one of these stimuli have allowed us to study mental sensory representations. Thus, the interest of this task is that it can be used to model positive psychotic-like states in mice, as recently described.< Réduire

Mots clés en anglais

Positive symptoms

Schizophrenia

Delusions

Reality testing

Representation-mediated learning

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112414

DOI

http://dx.doi.org/10.21769/BioProtoc.2358

Voir/Ouvrir

Métadonnées

Licence d’utilisation du document

Representation-mediated aversion as a model to study psychotic-like states in mice

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Representation-mediated aversion as a model to study psychotic-like states in mice

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche