LEYROLLE, Quentin; LAYE, Sophie; NADJAR, Agnes

doi:10.1016/j.neulet.2019.134348

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

LEYROLLE, Quentin
Nutrition et Neurobiologie intégrée [NutriNeuro]

LAYE, Sophie

Nutrition et Neurobiologie intégrée [NutriNeuro]

NADJAR, Agnes

Nutrition et Neurobiologie intégrée [NutriNeuro]

Langue

Article de revue

Ce document a été publié dans

Neuroscience Letters. 2019, vol. 708, p. 1-9

Résumé en anglais

Microglia are key players in brain function by maintaining brain homeostasis across lifetime. They participate to brain development and maturation through their ability to release neurotrophic factors, to remove immature synapses or unnecessary neural progenitors. They modulate neuronal activity in healthy adult brains and they also orchestrate the neuroinflammatory response in various pathophysiological contexts such as aging and neurodegenerative diseases. One of the main features of microglia is their high sensitivity to environmental factors, partly via the expression of a wide range of receptors. Recent data pinpoint that dietary fatty acids modulate microglia function. Both the quantity and the type of fatty acid are potent modulators of microglia physiology. The present review aims at dissecting the current knowledge on the direct and indirect mechanisms (focus on gut microbiota and hormones) through which fatty acids influence microglial physiology. We summarize main discoveries from in vitro and in vivo models on fatty acid-mediated microglial modulation. All these studies represent a promising field of research that could promote using nutrition as a novel therapeutic or preventive tool in diseases involving microglia dysfunctions.< Réduire

Mots clés en anglais

Fatty acids

Gut microbiota

Hormones

Inflammation

Microglia

Obesity

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Direct and indirect effects of lipids on microglia function

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche