PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies
Langue
EN
Article de revue
Ce document a été publié dans
Proceedings of the Nutrition Society. 2020-11, vol. 79, n° 4, p. 388-403
Résumé en anglais
PUFA of the n-3 and n-6 families are present in high concentration in the brain where they are major components of cell membranes. The main forms found in the brain are DHA (22 :6, n-3) and arachidonic acid (20:4, n-6). ...Lire la suite >
PUFA of the n-3 and n-6 families are present in high concentration in the brain where they are major components of cell membranes. The main forms found in the brain are DHA (22 :6, n-3) and arachidonic acid (20:4, n-6). In the past century, several studies pinpointed that modifications of n-3 and n-6 PUFA levels in the brain through dietary supply or genetic means are linked to the alterations of synaptic function. Yet, synaptopathies emerge as a common characteristic of neurodevelopmental disorders, neuropsychiatric diseases and some neurodegenerative diseases. Understanding the mechanisms of action underlying the activity of PUFA at the level of synapses is thus of high interest. In this frame, dietary supplementation in PUFA aiming at restoring or promoting the optimal function of synapses appears as a promising strategy to treat synaptopathies. This paper reviews the link between dietary PUFA, synapse formation and the role of PUFA and their metabolites in synaptic functions.< Réduire
Mots clés en anglais
Synaptic plasticity
DHA
EPA
Endocannabinoids
Oxylipins
Anandamide
Arachidonic acid
Cannabinoid receptor 1
Cannabinoid receptor 2
Cyclooxygenase 1. 2
N-docosahexaenoylethanolamide
Endocannabinoids
Y aminobutyric acid
G protein-coupled receptor
Linoleic acid
Long-chain
Long-term depression
Long-term potentiation
Platelet-activating factor
Phospholipase A2
Unités de recherche