MONCHAUX DE OLIVEIRA, Camille; POURTAU, Line; VANCASSEL, Sylvie; POUCHIEU, Camille; CAPURON, Lucile; GAUDOUT, David; CASTANON, Nathalie

doi:10.3390/nu13030904

Nutrition et Neurobiologie intégrée [NutriNeuro]

POURTAU, Line

VANCASSEL, Sylvie
Nutrition et Neurobiologie intégrée [NutriNeuro]

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Article de revue

Ce document a été publié dans

Nutrients. 2021-03, vol. 13, n° 3, p. 904

Résumé en anglais

Depressive disorders represent a major public health concern and display a continuously rising prevalence. Importantly, a large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need to identify further therapeutic strategies, including nutritional approaches using natural plant extracts with known beneficial impacts on health. In that context, growing evidence suggests that saffron could be a particularly promising candidate. This preclinical study aimed therefore to test its antidepressant-like properties in mice and to decipher the underlying mechanisms by focusing on monoaminergic neurotransmission, due to its strong implication in mood disorders. For this purpose, the behavioral and neurobiochemical impact of a saffron extract, Safr’Inside™ (6.5 mg/kg per os) was measured in naïve mice. Saffron extract reduced depressive-like behavior in the forced swim test. This behavioral improvement was associated with neurobiological modifications, particularly changes in serotonergic and dopaminergic neurotransmission, suggesting that Safr’Inside™ may share common targets with conventional pharmacological antidepressants. This study provides useful information on the therapeutic relevance of nutritional interventions with saffron extracts to improve management of mood disorders.< Réduire

Mots clés en anglais

Mood disorders

Nutritional interventions

Saffron extract

Safr’InsideTM

Depressive-like behavior

Monoaminergic neurotransmission

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112260

DOI

http://dx.doi.org/10.3390/nu13030904

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission

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Résumé en anglais

Mots clés en anglais

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Unités de recherche