DUCROCQ, Fabien; WALLE, Roman; CONTINI, Andrea; OUMMADI, Asma; CARABALLO, Baptiste; VAN DER VELDT, Suzanne; BOYER, Marie-Lou; ABY, Frank; TOLENTINO-CORTEZ, Tarson; HELBLING, Jean Christophe; MARTINE, Lucy; GREGOIRE, Stephane; CABARET, Stephanie; VANCASSEL, Sylvie; LAYE, Sophie; KANG, Jing Xuan; FIORAMONTI, Xavier; BERDEAUX, Olivier; BARREDA-GOMEZ, Gabriel; MASSON, Elodie; FERREIRA, Guillaume; MA, David W. L.; BOSCH BOUJU, Clementine; DE SMEDT-PEYRUSSE, Veronique; TRIFILIEFF, Pierre

doi:10.2139/ssrn.3382436

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DUCROCQ, Fabien
Nutrition et Neurobiologie intégrée [NutriNeuro]

WALLE, Roman

Nutrition et Neurobiologie intégrée [NutriNeuro]

CONTINI, Andrea

Nutrition et Neurobiologie intégrée [NutriNeuro]

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Cell Metabolism. 2019-01-01, vol. 31, n° 4, p. 755-772.e7

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Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 Polyunsaturated Fatty Acids (PUFAs) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational deficits. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor (D2R)-expressing medium spiny neurons (iMSNs) onto dopamine D1 receptor-expressing (d)MSNs in the nucleus accumbens, a main brain region for the modulation of motivation. Strikingly, transgenically preventing n-3 PUFA deficiency selectively in D2R-expressing neurons normalizes MSNs collateral inhibition and enhances motivation. These results constitute the first demonstration of a causal link between a behavioral deficit and n-3 PUFA decrease in a discrete neuronal population and suggest that lower n-3 PUFA biostatus in psychopathologies could participate to the etiology of reward-related symptoms.< Réduire

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Polyunsaturated fatty acids

Motivation

Dopamine

Nucleus accumbens

Medium spiny neurons

Electrophysiology

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Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

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