MADORE, Charlotte; LEYROLLE, Quentin; MOREL, Laurent; ROSSITTO, Moira; GREENHALGH, Andrew D.; DELPECH, Jean-Christophe; MARTINAT, Maud; BOSCH BOUJU, Clementine; BOUREL, Julien; RANI, B.; LACABANNE, Chloe; THOMAZEAU, Aurore; HOPPERTON, K. E.; BECCARI, Sol; SERE, Alexandra; AUBERT, Agnes; DE SMEDT-PEYRUSSE, Veronique; LECOURS, C.; BISHT, K.; FOURGEAUD, L.; GREGOIRE, Stephane; BRETILLON, Lionel; ACAR, N.; GRANT, N. J.; BADAUT, Jerome; GRESSENS, P.; SIERRA, Amanda; BUTOVSKY, O.; TREMBLAY, Marie-Eve; BAZINET, Richard P.; JOFFRE, Corinne; NADJAR, Agnes; LAYE, Sophie

doi:10.1038/s41467-020-19861-z

MADORE, Charlotte
Nutrition et Neurobiologie intégrée [NutriNeuro]

LEYROLLE, Quentin
Nutrition et Neurobiologie intégrée [NutriNeuro]

MOREL, Laurent
Nutrition et Neurobiologie intégrée [NutriNeuro]

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Article de revue

Ce document a été publié dans

Nature Communications. 2020-11-30, vol. 11, n° 1

Résumé en anglais

AbstractOmega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in Humans. However, the n-3 PUFAs deficiency-mediated mechanisms affecting the development of the central nervous system are poorly understood. Active microglial engulfment of synapses regulates brain development. Impaired synaptic pruning is associated with several neurodevelopmental disorders. Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development in mice. Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosis of synaptic elements in the rodent developing hippocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal morphology and affecting cognitive performance of the offspring. These findings provide a mechanistic insight into neurodevelopmental defects caused by maternal n-3 PUFAs dietary deficiency.< Réduire

Mots clés en anglais

Cellular neuroscience

Neurodevelopmental disorders

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112107

DOI

http://dx.doi.org/10.1038/s41467-020-19861-z

Projet Européen

Program Initiative d’Excellence

Project ANR

Infrastructure de Recherche Translationnelle pour les Biothérapies en Neurosciences

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain