JOFFRE, Corinne; DINEL, Anne Laure; CHATAIGNER, Mathilde; PALLET, Veronique; LAYE, Sophie

doi:10.3390/nu12030647

Nutrition et Neurobiologie intégrée [NutriNeuro]

DINEL, Anne Laure

Nutrition et Neurobiologie intégrée [NutriNeuro]

CHATAIGNER, Mathilde

Nutrition et Neurobiologie intégrée [NutriNeuro]

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Article de revue

Ce document a été publié dans

Nutrients. 2020-02-28, vol. 12, n° 3

Résumé en anglais

Aging is associated to cognitive decline, which can lead to loss of life quality, personal suffering, and ultimately neurodegenerative diseases. Neuroinflammation is one of the mechanisms explaining the loss of cognitive functions. Indeed, aging is associated to the activation of inflammatory signaling pathways, which can be targeted by specific nutrients with anti-inflammatory effects. Dietary n-3 polyunsaturated fatty acids (PUFAs) are particularly attractive as they are present in the brain, possess immunomodulatory properties, and are precursors of lipid derivates named specialized pro-resolving mediators (SPM). SPMs are crucially involved in the resolution of inflammation that is modified during aging, resulting in chronic inflammation. In this review, we first examine the effect of aging on neuroinflammation and then evaluate the potential beneficial effect of n-3 PUFA as precursors of bioactive derivates, particularly during aging, on the resolution of inflammation. Lastly, we highlight evidence supporting a role of n-3 PUFA during aging.< Réduire

Mots clés en anglais

Cognitive decline

n-3 polyunsaturated fatty acids

Neuroinflammation

Resolution of inflammation

Specialized pro-resolving mediators

Aging

URI

https://oskar-bordeaux.fr/handle/20.500.12278/112071

DOI

http://dx.doi.org/10.3390/nu12030647

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging

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