BUSQUETS-GARCIA, Arnau; OLIVEIRA DA CRUZ, Jose F.; TERRAL, Geoffrey; PAGANO ZOTTOLA, Antonio C.; SORIA-GOMEZ, Edgar; CONTINI, Andrea; MARTIN, Hugo; REDON, Bastien; VARILH, Marjorie; IOANNIDOU, Christina; DRAGO, Filippo; MASSA, Federico; FIORAMONTI, Xavier; TRIFILIEFF, Pierre; FERREIRA, Guillaume; MARSICANO, Giovanni

doi:10.1016/j.neuron.2018.08.014

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Article de revue

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Neuron. 2018, vol. 99, n° 6, p. 1247-1259.e7

Résumé en anglais

By priming brain circuits, associations between low-salience stimuli often guide future behavioral choices through a process known as mediated or inferred learning. However, the precise neurobiological mechanisms of these incidental associations are largely unknown. Using sensory preconditioning procedures, we show that type 1 cannabinoid receptors (CB1R) in hippocampal GABAergic neurons are necessary and sufficient for mediated but not direct learning. Deletion and re-expression of CB1R in hippocampal GABAergic neurons abolishes and rescues mediated learning, respectively. Interestingly, paired presentations of low-salience sensory cues induce a specific protein synthesis-dependent enhancement of hippocampal CB1R expression and facilitate long-term synaptic plasticity at inhibitory synapses. CB1R blockade or chemogenetic manipulations of hippocampal GABAergic neurons upon preconditioning affect incidental associations, as revealed by impaired mediated learning. Thus, CB1R-dependent control of inhibitory hippocampal neurotransmission mediates incidental associations, allowing future associative inference, a fundamental process for everyday life, which is altered in major neuropsychiatric diseases. VIDEO ABSTRACT.< Réduire

Mots clés en anglais

Animals

CB1

endocannabinoids

GABA

GABAergic Neurons

higher-order associations

hippocampus

Hippocampus

incidental learning

Long-Term Synaptic Depression

mediated learning

Mice

Neuronal Plasticity

Receptor

Cannabinoid

Synapses

Synaptic Transmission

Western immunoblotting

electrophysiology (LTP

I-LTD)

URI

https://oskar-bordeaux.fr/handle/20.500.12278/110263

DOI

http://dx.doi.org/10.1016/j.neuron.2018.08.014

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Hippocampal CB1 Receptors Control Incidental Associations

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Hippocampal CB1 Receptors Control Incidental Associations

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