ZEKI AL HAZZOURI, Adina; VITTINGHOFF, Eric; HOANG, Tina; GOLDEN, Sherita H.; FITZPATRICK, Annette L.; ZHANG, Adina; GRASSET, Leslie; YAFFE, Kristine

doi:10.1002/alz.12367

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ZEKI AL HAZZOURI, Adina

VITTINGHOFF, Eric

HOANG, Tina

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Alzheimer's and Dementia. 2021-05-13

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INTRODUCTION: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women. METHODS: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used. RESULTS: Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men. CONCLUSIONS: With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.< Réduire

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Body mass index

Cohort

Dementia

Life course

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Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort

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