Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | ZEKI AL HAZZOURI, Adina | |
| dc.contributor.author | VITTINGHOFF, Eric | |
| dc.contributor.author | HOANG, Tina | |
| dc.contributor.author | GOLDEN, Sherita H. | |
| dc.contributor.author | FITZPATRICK, Annette L. | |
| dc.contributor.author | ZHANG, Adina | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GRASSET, Leslie | |
| dc.contributor.author | YAFFE, Kristine | |
| dc.date.accessioned | 2021-08-24T12:29:43Z | |
| dc.date.available | 2021-08-24T12:29:43Z | |
| dc.date.issued | 2021-05-13 | |
| dc.identifier.issn | 1552-5260 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110210 | |
| dc.description.abstractEn | INTRODUCTION: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women. METHODS: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used. RESULTS: Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men. CONCLUSIONS: With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Body mass index | |
| dc.subject.en | Cohort | |
| dc.subject.en | Dementia | |
| dc.subject.en | Life course | |
| dc.title.en | Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/alz.12367 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33984188 | en_US |
| bordeaux.journal | Alzheimer's and Dementia | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | VINTAGE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03325193 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-08-24T12:29:47Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2021-05-13&rft.eissn=1552-5260&rft.issn=1552-5260&rft.au=ZEKI%20AL%20HAZZOURI,%20Adina&VITTINGHOFF,%20Eric&HOANG,%20Tina&GOLDEN,%20Sherita%20H.&FITZPATRICK,%20Annette%20L.&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||