RACHEDI, K. O.; OUK, T. S.; BAHADI, R.; BOUZINA, A.; DJOUAD, S. E.; BECHLEM, K.; ZERROUKI, R.; BEN HADDA, T.; ALMALKI, F.; BERREDJEM, M.

doi:10.1016/j.molstruc.2019.07.053

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

RACHEDI, K. O.

OUK, T. S.
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

BAHADI, R.

Idioma

Article de revue

Este ítem está publicado en

Journal of Molecular Structure. 2019, vol. 1197, p. 196-203

Resumen en inglés

In the present study, we investigated the cytotoxic activity of three compounds prepared starting from amino acids. These derivatives were evaluated for their in vitro antitumor activity against human cell lines (PRI, K562 and JURKAT). Their cytotoxicity was also evaluated at different concentrations on several cell lines. On the other hand, DFT calculation has been used to analyze the electronic and geometric characteristics. The HOMO, LUMO and gap energies were also deduced for the stable structure for each compound. These results will be correlated with the experimental values. The bioinformatic POM (Petra/Osiris/Molinspiration) analyses of the relative cytotoxicity of these derivatives are reported in comparison to Chlorambucil. (C) 2019 Published by Elsevier B.V.< Leer menos

Palabras clave en inglés

Amidophosphonate

Cytotoxicity activity

DFT calculations

Descriptors

POM analyses

Metadatos

Compartir este ítem

Licencia de uso del documento

Synthesis, DFT and POM analyses of cytotoxicity activity of alpha-camidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación