Highly loaded nanoparticles with gentamicin sulfate by combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials
dc.contributor.author | PICHAVANT, Loic | |
dc.contributor.author | CARRIE, Helene | |
dc.contributor.author | DURRIEU, Marie-Christine | |
dc.contributor.author | HEROGUEZ, Valerie | |
dc.date.accessioned | 2020-09-03T07:56:09Z | |
dc.date.available | 2020-09-03T07:56:09Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10831 | |
dc.description.abstractEn | Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces | |
dc.language.iso | en | |
dc.title.en | Highly loaded nanoparticles with gentamicin sulfate by combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1039/C6PY01774F | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | Polymer Chemistry | |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymer%20Chemistry&rft.date=2016&rft.au=PICHAVANT,%20Loic&CARRIE,%20Helene&DURRIEU,%20Marie-Christine&HEROGUEZ,%20Valerie&rft.genre=article |
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