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Effects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats: modulation of it by rutin and other micronutrients

dc.rights.licenseopenen_US
dc.contributor.authorGATINEAU, Eva
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorCLUZET, Stephanie
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
dc.contributor.authorPAPET, Isabelle
dc.contributor.authorMIGNE, Carole
dc.contributor.authorREMOND, Didier
dc.contributor.authorDARDEVET, Dominique
dc.contributor.authorPOLAKOF, Sergio
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.contributor.authorMOSONI, Laurent
dc.date.accessioned2020-09-02T09:18:01Z
dc.date.available2020-09-02T09:18:01Z
dc.date.issued2018
dc.identifier.issn2042-6496en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10768
dc.description.abstractEnLittle is still known about brain protein synthesis. In order to increase our knowledge of it, we aimed to modulate brain protein synthesis rates through aging, variations in nutritional state (fed state vs. fasted state), high sucrose diet and micronutrient supplementation. Four groups of 16 month-old male rats were fed for five months with a diet containing either 13% or 62% sucrose (wheat starch was replaced with sucrose), supplemented or not with rutin (5 g kg-1 diet), vitamin E (4×), A (2×), D (5×), selenium (10×) and zinc (+44%) and compared with an adult control group. We measured cerebellum protein synthesis and hippocampus gene expression of antioxidant enzymes, inflammatory cytokines and transcription factors. We showed that cerebellum protein synthesis was unchanged by the nutritional state, decreased during aging (-8%), and restored to the adult level by micronutrient supplementation. Sucrose diet did not change protein synthesis but reduced the protein content. Micronutrient supplementation had no effect in sucrose fed rats. Hippocampus gene expressions were affected by age (an increase of TNF-α), sucrose treatment (an increase of IL-1β and IL-6), and micronutrient supplementation (a decrease of heme oxygenase, catalase, glutathione peroxidase, TNF-α, and Nrf2). We noted that cerebellum protein synthesis and hippocampus TNF-α gene expression were modulated by the same factors: they were affected by aging and micronutrient supplementation and unchanged by feeding and by high sucrose diet.
dc.language.isoENen_US
dc.subjectÉtat nutritionnel
dc.subjectSynthèse de protéine
dc.subjectVieillissement
dc.subjectSaccharose
dc.subjectRutine
dc.subjectVieillissement Cérébral
dc.subjectRat
dc.subjectMicronutriment
dc.title.enEffects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats: modulation of it by rutin and other micronutrients
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/c7fo01953jen_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed29741190en_US
bordeaux.journalFood and Functionen_US
bordeaux.page2922-2930en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.issue5en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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