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dc.rights.licenseopenen_US
dc.contributor.authorVAN HUL, Matthias
dc.contributor.authorGEURTS, Lucie
dc.contributor.authorPLOVIER, Hubert
dc.contributor.authorDRUART, Céline
dc.contributor.authorEVERARD, Amandine
dc.contributor.authorSTÅHLMAN, Marcus
dc.contributor.authorRHIMI, Moez
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorCHIRA, Kleopatra
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorTEISSEDRE, Pierre Louis
dc.contributor.authorDELZENNE, Nathalie M.
dc.contributor.authorMAGUIN, Emmanuelle
dc.contributor.authorGUILBOT, Angèle
dc.contributor.authorBROCHOT, Amandine
dc.contributor.authorGÉRARD, Philippe
dc.contributor.authorBÄCKHED, Fredrik
dc.contributor.authorCANI, Patrice D.
dc.date.accessioned2020-08-31T11:35:06Z
dc.date.available2020-08-31T11:35:06Z
dc.date.issued2018
dc.identifier.issn0193-1849en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10713
dc.description.abstractEnIncreasing evidence suggests that polyphenols have a significant potential in the prevention and treatment of risk factors associated with metabolic syndrome. The objective of this study was to assess the metabolic outcomes of two polyphenol-containing extracts from cinnamon bark (CBE) and grape pomace (GPE) on C57BL/6J mice fed a high-fat diet (HFD) for 8 weeks. Both CBE and GPE were able to decrease fat mass gain and adipose tissue inflammation in mice fed a HFD without reducing food intake. This was associated with reduced liver steatosis and lower plasma non-esterified fatty acids levels. We also observed a beneficial effect on glucose homeostasis as evidenced by an improved glucose tolerance and a lower insulin resistance index. These ameliorations of the overall metabolic profile were associated to a significant impact on the microbial composition, which was more profound for the GPE than for the CBE. At the genus level, Peptococcus were decreased in the CBE group. In the GPE treated group, several key genera that have been previously found to be linked with HFD, metabolic effects and gut barrier integrity were affected: we observed a decrease of Desulfovibrio, Lactococcus, whereas Allobaculum and Roseburia were increased. In addition, the expression of several antimicrobial peptides and tight junction proteins was increased in response to both CBE and GPE supplementation, indicating an improvement of the gut barrier function. Collectively, these data suggest that CBE and GPE can ameliorate the overall metabolic profile of mice on a high-fat diet, partly by acting on the gut microbiota.
dc.language.isoENen_US
dc.subject.enDiabetes
dc.subject.enGut Barrier
dc.subject.enGut Microbiota
dc.subject.enObesity
dc.subject.enPolyphenols
dc.title.enReduced obesity, diabetes and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier
dc.title.alternativeAm. j. physiol., endocrinol. metab.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1152/ajpendo.00107.2017en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed28874357en_US
bordeaux.journalAmerican Journal of Physiology. Endocrinology and Metabolismen_US
bordeaux.pageE334-E352en_US
bordeaux.volume314en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.issue4en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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