JOBIN, M. L.; D. ALVES, Isabel

doi:10.1007/978-1-4939-9179-2_1

D. ALVES, Isabel
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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Chapitre d'ouvrage

Ce document a été publié dans

Methods in Molecular Biology. 2019, vol. 1964, p. 3-15

Springer

Résumé en anglais

Membrane-active peptides include a variety of molecules such as antimicrobial (AMP), cell-penetrating (CPP), viral, and amyloid peptides that are implicated in several pathologies. They constitute important targets because they are either at the basis of novel therapies (drug delivery for CPPs or antimicrobial activity for AMPs) or they are the agents causing these pathologies (viral and amyloid peptides). They all share the common property of interacting with the cellular lipid membrane in their mode of action. Therefore, a better understanding of the peptide/lipid (P/L) interaction is essential to help decipher their mechanism of action. Among the different biophysical methods that can be used to fully characterize P/L interactions, differential scanning calorimetry (DSC) allows determining the peptide effect on the lipid phase transitions, a property that reflects the P/L interaction mode. A general protocol for classical DSC experiments for P/L studies will be provided.< Réduire

Mots clés en anglais

Membrane active peptides

peptide/lipid interaction

differential scanning calorimetry

lipid phase transition

thermodynamic behavior

URI

https://oskar-bordeaux.fr/handle/20.500.12278/106540

DOI

http://dx.doi.org/10.1007/978-1-4939-9179-2_1

Unités de recherche

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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The Contribution of Differential Scanning Calorimetry for the Study of Peptide/Lipid Interactions

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Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche