MALDONADO-CARMONA, Nidia; OUK, Tan-Sothea; VILLANDIER, Nicolas; CALLISTE, Claude Alain; CALVETE, Mario J. F.; PEREIRA, Mariette M.; LEROY-LHEZ, Stephanie

doi:10.3390/antibiotics10050513

OUK, Tan-Sothea
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

VILLANDIER, Nicolas

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Article de revue

Ce document a été publié dans

Antibiotics. 2021, vol. 10, n° 5

Résumé en anglais

Lignin has recently attracted the attention of the scientific community, as a suitable raw material for biomedical applications. In this work, acetylated lignin was used to encapsulate five different porphyrins, aiming to preserve their photophysical properties, and for further use as antibacterial treatment. The obtained nanoparticles were physically characterized, through dynamic light scattering size measurement, polydispersity index and zeta potential values. Additionally, the photophysical properties of the nanoparticles, namely UV-vis absorption, fluorescence emission, singlet oxygen production and photobleaching, were compared with those of the free porphyrins. It was found that all the porphyrins were susceptible to encapsulation, with an observed decrease in their fluorescence quantum yield and singlet oxygen production. These nanoparticles were able to exert an effective photodynamic bactericide effect (blue-LED light, 450-460 nm, 15 J/cm(2)) on Staphylococcus aureus and Escherichia coli. Furthermore, it was achieved a photodynamic bactericidal activity on an encapsulated lipophillic porphyrin, where the free porphyrin failed to diminish the bacterial survival. In this work it was demonstrated that acetylated lignin encapsulation works as a universal, cheap and green material for the delivery of porphyrins, while preserving their photophysical properties.< Réduire

Mots clés en anglais

tetrapyrrolic compounds

photodynamic therapy

lignin valorization

URI

https://oskar-bordeaux.fr/handle/20.500.12278/106483

DOI

http://dx.doi.org/10.3390/antibiotics10050513

Lien vers les données de la recherche

https://www.mdpi.com/2079-6382/10/5/513/s1

Projet Européen

ERC Horizon H2020
H2020 Marie Skłodowska-Curie Actions

Unités de recherche

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles