POIZOT-MARTIN, I.; ROSENTHAL, E.; GILBERT, Camille; CANO, C. E.; SIMON, A.; LASCOUX-COMBE, C.; ALRIC, L.; GERVAIS, A.; NEAU, D.; ESTERLE, Laure; SALMON, D.; SOGNI, P.; WITTKOP, Linda

doi:10.1097/qai.0000000000001940

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POIZOT-MARTIN, I.

ROSENTHAL, E.

GILBERT, Camille
Bordeaux population health [BPH]

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Journal of acquired immune deficiency syndromes (1999). 2019-04-01, vol. 80, n° 4, p. 461-466

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BACKGROUND: HCV and HIV infections are associated with higher risk of autoimmune diseases and T-cell dysfunction. SETTING: We evaluate prevalence and factors associated with the presence of autoimmune antinuclear (ANA), anti-smooth muscle actin (aSMA) and anti-liver kidney microsomes (aLKM1) antibodies (Ab) in HCV/HIV coinfected patients during the post-cART era. METHODS: cross-sectional observational study, nested in the ANRS CO13 HEPAVIH cohort (NCT number: NCT03324633). We selected patients with both ANA testing and T-cell immunophenotyping determination during the cohort follow-up and collected aLKM1 and aSMA data when available. Logistic regression models were built to determine factors associated with the presence of auto-Ab. RESULTS: 223 HCV/HIV coinfected patients fulfilled selection criteria. Prevalence of ANA and aSMA was 43.5% and 23.2%, respectively, and both were detected in 13.3% of patients. Isolated aSMA were detected in 9.9% and aLKM1 in 2 patients. In multivariable analysis, only a low nadir CD4 T-cell count was significantly associated with ANA detection. CONCLUSION: ANA and aSMA detection remain frequent in HCV/HIV coinfected patients during post-cART era despite fair immune restoration. These results advocate for a close monitoring of ANA before immune checkpoint inhibitor therapy in these patients with greater caution for those with a low nadir CD4 T- cell count.< Réduire

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MORPH3Eus

ANRS CO13 HEPAVIH

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Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients

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