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Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients

dc.rights.licenseopenen_US
dc.contributor.authorPOIZOT-MARTIN, I.
dc.contributor.authorROSENTHAL, E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGILBERT, Camille
dc.contributor.authorCANO, C. E.
dc.contributor.authorSIMON, A.
dc.contributor.authorLASCOUX-COMBE, C.
dc.contributor.authorALRIC, L.
dc.contributor.authorGERVAIS, A.
dc.contributor.authorNEAU, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
dc.contributor.authorSALMON, D.
dc.contributor.authorSOGNI, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.date.accessioned2020-07-09T14:25:39Z
dc.date.available2020-07-09T14:25:39Z
dc.date.issued2019-04-01
dc.identifier.issn1944-7884 (Electronic) 1525-4135 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10368
dc.description.abstractEnBACKGROUND: HCV and HIV infections are associated with higher risk of autoimmune diseases and T-cell dysfunction. SETTING: We evaluate prevalence and factors associated with the presence of autoimmune antinuclear (ANA), anti-smooth muscle actin (aSMA) and anti-liver kidney microsomes (aLKM1) antibodies (Ab) in HCV/HIV coinfected patients during the post-cART era. METHODS: cross-sectional observational study, nested in the ANRS CO13 HEPAVIH cohort (NCT number: NCT03324633). We selected patients with both ANA testing and T-cell immunophenotyping determination during the cohort follow-up and collected aLKM1 and aSMA data when available. Logistic regression models were built to determine factors associated with the presence of auto-Ab. RESULTS: 223 HCV/HIV coinfected patients fulfilled selection criteria. Prevalence of ANA and aSMA was 43.5% and 23.2%, respectively, and both were detected in 13.3% of patients. Isolated aSMA were detected in 9.9% and aLKM1 in 2 patients. In multivariable analysis, only a low nadir CD4 T-cell count was significantly associated with ANA detection. CONCLUSION: ANA and aSMA detection remain frequent in HCV/HIV coinfected patients during post-cART era despite fair immune restoration. These results advocate for a close monitoring of ANA before immune checkpoint inhibitor therapy in these patients with greater caution for those with a low nadir CD4 T- cell count.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.subject.enANRS CO13 HEPAVIH
dc.title.enNadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients
dc.title.alternativeJ Acquir Immune Defic Syndren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qai.0000000000001940en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30570526en_US
bordeaux.journalJournal of acquired immune deficiency syndromes (1999)en_US
bordeaux.page461-466en_US
bordeaux.volume80en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.exportfalse
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