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Investigation of Low-Energy Proton Effects on Aptamer Performance for Astrobiological Applications

hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorBAQUE, Mickaël
hal.structure.identifierLaboratoire d'Astrophysique de Bordeaux [Pessac] [LAB]
hal.structure.identifierObservatoire aquitain des sciences de l'univers [OASU]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
hal.structure.identifierLaboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux [L3AB]
dc.contributor.authorLE POSTOLLEC, A.
hal.structure.identifierDépartement de pharmacochimie moléculaire [DPM]
dc.contributor.authorRAVELET, C.
hal.structure.identifierDépartement de pharmacochimie moléculaire [DPM]
dc.contributor.authorPEYRIN, E.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorCOUSSOT, G.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorDESVIGNES, Isabelle
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, S.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMORETTO, P.
hal.structure.identifierLaboratoire d'Astrophysique de Bordeaux [Pessac] [LAB]
hal.structure.identifierObservatoire aquitain des sciences de l'univers [OASU]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
hal.structure.identifierLaboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux [L3AB]
dc.contributor.authorDOBRIJEVIC, M.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorVANDENABEELE-TRAMBOUZE, O.
dc.date.issued2011
dc.identifier.issn1531-1074
dc.description.abstractEnBiochips are promising instruments for the search for organic molecules in planetary environments. Nucleic acid aptamers are powerful affinity receptors known for their high affinity and specificity, and therefore are of great interest for space biochip development. A wide variety of aptamers have already been selected toward targets of astrobiological interest (from amino acids to microorganisms). We present a first study to test the resistance of these receptors to the constraints of the space environment. The emphasis is on the effect of cosmic rays on the molecular recognition properties of DNA aptamers. Experiments on beam-line facilities have been conducted with 2 MeV protons and fluences much higher than expected for a typical mission to Mars. Our results show that this irradiation process did not affect the performances of DNA aptamers as molecular recognition tools.
dc.language.isoen
dc.publisherMary Ann Liebert
dc.subject.enAptamer
dc.subject.enBiochip
dc.subject.enMicroarray
dc.subject.enCosmic radiation
dc.title.enInvestigation of Low-Energy Proton Effects on Aptamer Performance for Astrobiological Applications
dc.typeArticle de revue
dc.identifier.doi10.1089/AST.2010.0520
dc.subject.halPlanète et Univers [physics]/Astrophysique [astro-ph]/Planétologie et astrophysique de la terre [astro-ph.EP]
dc.subject.halPhysique [physics]/Astrophysique [astro-ph]/Planétologie et astrophysique de la terre [astro-ph.EP]
bordeaux.journalAstrobiology
bordeaux.page207-211
bordeaux.volume11
bordeaux.peerReviewedoui
hal.identifierhal-00589210
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00589210v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Astrobiology&rft.date=2011&rft.volume=11&rft.spage=207-211&rft.epage=207-211&rft.eissn=1531-1074&rft.issn=1531-1074&rft.au=BAQUE,%20Micka%C3%ABl&LE%20POSTOLLEC,%20A.&RAVELET,%20C.&PEYRIN,%20E.&COUSSOT,%20G.&rft.genre=article


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