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Impact of polyphenols on receptor-ligand interactions by NMR: the case of neurotensin (NT)-neurotensin receptor fragment (NTS1) complex

dc.rights.licenseopenen_US
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.contributor.authorPETIT, Eva
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPOUYSEGU, Laurent
hal.structure.identifierLaboratoire de physique et biophysique
dc.contributor.authorMONTI, Jean-Pierre
dc.contributor.authorBONDON, Arnaud
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorSYLLA, Tahiri
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMERILLON, Jean-Michel
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorQUIDEAU, Stephane
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorDA COSTA, Gregory
dc.date.accessioned2020-07-02T20:34:19Z
dc.date.available2020-07-02T20:34:19Z
dc.date.issued2019
dc.identifier.issn0739-1102en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8509
dc.description.abstractEnLigand-receptor interactions can be implicated in many pathological events such as chronic neurodegenerative diseases. Thus, the discovery of molecules disrupting this type of interactions could be an interesting therapeutic approach. Polyphenols are well known for their affinity for proteins and several studies have characterized these direct interactions. But studying the direct influence of multi-therapeutic drugs on a ligand-receptor complex relevant to a neurodegenerative disorder is a challenging issue. Solution NMR, molecular modeling and iterative calculations were used to obtain information about the interaction between a phenolic compound, α-glucogallin (α-2) and a ligand/fragment receptor complex neurotensin (NT) and its receptor NTS1. The α-2 was shown to bind to NT and a peptidic fragment of its NTS1 receptor, independently. Although the formation of the corresponding ligand-receptor complex did not seem to be affected, this experimental modeling protocol will enable the evaluation of other anti-amyloidogenic compounds such as blockers of NT-NTS1 binding. These types of studies help in understanding the specificity and influence in binding and can provide information to develop new molecules with a putative pharmacological interest.
dc.language.isoENen_US
dc.subject.enNmr
dc.subject.enInteraction
dc.subject.enNeurodegenerative Diseases
dc.subject.enPhenolic Compounds
dc.subject.enReceptor–Ligand Complex
dc.title.enImpact of polyphenols on receptor-ligand interactions by NMR: the case of neurotensin (NT)-neurotensin receptor fragment (NTS1) complex
dc.title.alternativeJ. biomol. struct. dyn.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1080/07391102.2019.1608863en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed31046599en_US
bordeaux.journalJournal of Biomolecular Structure and Dynamicsen_US
bordeaux.page1-12en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Biomolecular%20Structure%20and%20Dynamics&rft.date=2019&rft.spage=1-12&rft.epage=1-12&rft.eissn=0739-1102&rft.issn=0739-1102&rft.au=RICHARD,%20Tristan&PETIT,%20Eva&POUYSEGU,%20Laurent&MONTI,%20Jean-Pierre&BONDON,%20Arnaud&rft.genre=article


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