HARRIS, William S.; TINTLE, Nathan L.; IMAMURA, Fumiaki; QIAN, Frank; KORAT, Andres V. Ardisson; MARKLUND, Matti; DJOUSSE, Luc; BASSETT, Julie K.; CARMICHAEL, Pierre-Hugues; CHEN, Yun-Yu; HIRAKAWA, Yoichiro; KÜPERS, Leanne K.; LAGUZZI, Federica; LANKINEN, Maria; MURPHY, Rachel A.; SAMIERI, Cecilia; SENN, Mackenzie; SHI, Peilin; VIRTANEN, Jyrki K.; BROUWER, Ingeborg A.; CHIEN, Kuo-Liong; EIRIKSDOTTIR, Gudny; FOROUHI, Nita G.; GELEIJNSE, Johanna M.; GILES, Graham G.; GUDNASON, Vilmundur; HELMER, Catherine; HODGE, Allison; JACKSON, Rebecca; KHAW, Kay-Tee; LAAKSO, Markku; LAI, Heidi; LAURIN, Danielle; LEANDER, Karin; LINDSAY, Joan; MICHA, Renata; MURSU, Jaako; NINOMIYA, Toshiharu; POST, Wendy; PSATY, Bruce M.; RISERUS, Ulf; ROBINSON, Jennifer G.; SHADYAB, Aladdin H.; SNETSELAAR, Linda; SALA-VILA, Aleix; SUN, Yangbo; STEFFEN, Lyn M.; TSAI, Michael Y.; WAREHAM, Nicolas J.; WOOD, Alexis C.; WU, Jason H. Y.; HU, Frank; SUN, Qi; SISCOVICK, David S.; LEMAITRE, Rozenn N.; MOZAFFARIAN, Dariush

doi:10.1038/s41467-021-22370-2

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Nature Communications. 2021-04-22, vol. 12, n° 1, p. 2329

Résumé en anglais

The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.< Réduire

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Predictive markers

Risk factors

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https://oskar-bordeaux.fr/handle/20.500.12278/79311

DOI

http://dx.doi.org/10.1038/s41467-021-22370-2

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

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