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TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.

hal.structure.identifierMaintenance Myélinique et Neuropathies Périphériques [MMNP]
dc.contributor.authorSARRAZY, Vincent
hal.structure.identifierMaintenance Myélinique et Neuropathies Périphériques [MMNP]
dc.contributor.authorVEDRENNE, Nicolas
hal.structure.identifierMaintenance Myélinique et Neuropathies Périphériques [MMNP]
dc.contributor.authorBILLET, Fabrice
dc.contributor.authorBORDEAU, Nelly
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorLEPREUX, Sébastien
hal.structure.identifierService de pathologie [Bordeaux]
dc.contributor.authorVITAL, Anne
hal.structure.identifierHoméostasie Cellulaire et Pathologies [HCP]
hal.structure.identifierService d'Immunologie et immunogénétique [CHU Limoges]
dc.contributor.authorJAUBERTEAU-MARCHAN, Marie-Odile
hal.structure.identifierMaintenance Myélinique et Neuropathies Périphériques [MMNP]
dc.contributor.authorDESMOULIÈRE, Alexis
dc.date.accessioned2021-06-10T07:05:58Z
dc.date.available2021-06-10T07:05:58Z
dc.date.issued2011-12-08
dc.identifier.issn0304-3835
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79055
dc.description.abstractEnThe Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment. Activation of the Fas pathway or of the TLR4 pathway induced cell proliferation. However, simultaneous treatment with agonist antibody and LPS decreased proliferation. This anti-proliferative effect was caspase dependent, and a decreased cell migration and matrix metalloproteinase (MMP)-9 expression were also observed. Both TLR4 and MMP-9 were highly expressed in human glioblastoma tissues. These data suggest that TLR4 signal transduction pathways neutralize proliferation and migration induced by Fas pathway activation in glioblastoma cell lines.
dc.language.isoen
dc.publisherElsevier
dc.subject.meshAntigens, CD95
dc.subject.meshCell Line, Tumor
dc.subject.meshCell Movement
dc.subject.meshCell Proliferation
dc.subject.meshGlioblastoma
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMatrix Metalloproteinase 9
dc.subject.meshSignal Transduction
dc.subject.meshToll-Like Receptor 4
dc.title.enTLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.canlet.2011.07.018
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
bordeaux.journalCancer Letters
bordeaux.page195-202
bordeaux.volume311
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026*
bordeaux.issue2
bordeaux.institutionCNRS
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedoui
hal.identifierhal-00873131
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00873131v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancer%20Letters&rft.date=2011-12-08&rft.volume=311&rft.issue=2&rft.spage=195-202&rft.epage=195-202&rft.eissn=0304-3835&rft.issn=0304-3835&rft.au=SARRAZY,%20Vincent&VEDRENNE,%20Nicolas&BILLET,%20Fabrice&BORDEAU,%20Nelly&LEPREUX,%20S%C3%A9bastien&rft.genre=article


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