Composition and properties of silver-containing calcium carbonate–calcium phosphate bone cement
hal.structure.identifier | Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT] | |
dc.contributor.author | JACQUART, Sylvaine | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | SIADOUS, Robin | |
dc.contributor.author | HÉNOCQ-PIGASSE, Christel | |
hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
dc.contributor.author | BAREILLE, Reine | |
dc.contributor.author | ROQUES, Christine | |
hal.structure.identifier | Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT] | |
dc.contributor.author | REY, Christian | |
hal.structure.identifier | Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT] | |
dc.contributor.author | COMBES, Christèle | |
dc.date.accessioned | 2021-06-10T07:05:56Z | |
dc.date.available | 2021-06-10T07:05:56Z | |
dc.date.issued | 2013-12 | |
dc.identifier.issn | 0957-4530 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/79053 | |
dc.description.abstractEn | The introduction of silver, either in the liquid phase (as silver nitrate solution: Ag(L)) or in the solid phase (as silver phosphate salt: Ag(S)) of calcium carbonate–calcium phosphate (CaCO3–CaP) bone cement, its influence on the composition of the set cement (C-Ag(L)and C-Ag(S) cements with a Ca/Ag atomic ratio equal to 10.3) and its biological properties were investigated. The fine characterisation of the chemical setting of silver-doped and reference cements was performed using FTIR spectroscopy. We showed that the formation of apatite was enhanced from the first hours of maturation of C-Ag(L) cement in comparison with the reference cement, whereas a longer period of maturation (about 10 h) was required to observe this increase for C-Ag(S) cement, although in both cases, silver was present in the set cements mainly as silver phosphate. The role of silver nitrate on the setting chemical reaction is discussed and a chemical scheme is proposed. Antibacterial activity tests (S. aureus and S. epidermidis) and in vitro cytotoxicity tests (human bone marrow stromal cells (HBMSC)) showed that silver-loaded CaCO3–CaP cements had antibacterial properties (anti-adhesion and anti-biofilm formation) without a toxic effect on HBMSC cells, making C-Ag(S) cement a promising candidate for the prevention of bone implant-associated infections. | |
dc.language.iso | en | |
dc.publisher | Springer Verlag | |
dc.subject.en | Bone cement | |
dc.subject.en | Silver | |
dc.subject.en | Physico-chemistry | |
dc.subject.en | Antibacterial activity | |
dc.subject.en | Cytotoxicity | |
dc.title.en | Composition and properties of silver-containing calcium carbonate–calcium phosphate bone cement | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1007/s10856-013-5014-2 | |
dc.subject.hal | Chimie/Matériaux | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | |
dc.subject.hal | Sciences de l'ingénieur [physics]/Matériaux | |
bordeaux.journal | Journal of Materials Science: Materials in Medicine | |
bordeaux.page | pp. 2665-2675 | |
bordeaux.volume | Vol. 24 | |
bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | * |
bordeaux.issue | n° 12 | |
bordeaux.institution | CNRS | |
bordeaux.institution | INSERM | |
bordeaux.institution | CHU de Bordeaux | |
bordeaux.institution | Institut Bergonié | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01153078 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01153078v1 | |
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