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A Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast

dc.rights.licenseopenen_US
dc.contributor.authorBLEIN-NICOLAS, Melisande
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorALBERTIN, Warren
dc.contributor.authorDA SILVA, Telma
dc.contributor.authorVALOT, Benoit
dc.contributor.authorBALLIAU, Thierry
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMASNEUF POMAREDE, Isabelle
ORCID: 0000-0002-8806-8944
IDREF: 13239667X
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorBELY, Marina
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMARULLO, Philippe
dc.contributor.authorSICARD, Delphine
dc.contributor.authorDILLMANN, Christine
dc.contributor.authorDE VIENNE, Dominique
dc.contributor.authorZIVY, Michel
dc.date.accessioned2021-06-08T08:45:33Z
dc.date.available2021-06-08T08:45:33Z
dc.date.issued2015-05-13
dc.identifier.issn1535-9476en_US
dc.identifier.urihttps://www.researchgate.net/publication/276361029_A_Systems_Approach_to_Elucidate_Heterosis_of_Protein_Abundances_in_Yeast
dc.identifier.urioai:researchgate.net:276361029
dc.identifier.urioai:crossref.org:10.1074/mcp.m115.048058
dc.identifier.urioadoi:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528237
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/78850
dc.description.abstractEnHeterosis is a universal phenomenon that has major implications in evolution and is of tremendous agro-economic value. To study the molecular manifestations of heterosis and to find factors that maximize its strength, we implemented a large-scale proteomic experiment in yeast. We analyzed the inheritance of 1,396 proteins in 55 inter- and intraspecific hybrids obtained from Saccharomyces cerevisiae and S. uvarum that were grown in grape juice at two temperatures. We showed that the proportion of heterotic proteins was highly variable depending on the parental strain and on the temperature considered. For intraspecific hybrids, this proportion was higher at nonoptimal temperature. Unexpectedly, heterosis for protein abundance was strongly biased toward positive values in interspecific hybrids but not in intraspecific hybrids. Computer modeling showed that this observation could be accounted for by assuming concave relationships between protein abundances and their controlling factors, in line with the metabolic model of heterosis. These results point to nonlinear processes that could play a central role in heterosis.
dc.language.isoENen_US
dc.sourceresearchgate
dc.sourcecrossref
dc.sourceoadoi_repo
dc.title.enA Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast
dc.title.alternativeMol Cell Proteomicsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1074/mcp.m115.048058en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed25971257en_US
bordeaux.journalMolecular and Cellular Proteomicsen_US
bordeaux.page2056-2071en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesUnité de Recherche Oenologie - EA 4577en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20and%20Cellular%20Proteomics&rft.date=2015-05-13&rft.volume=14&rft.issue=8&rft.spage=2056-2071&rft.epage=2056-2071&rft.eissn=1535-9476&rft.issn=1535-9476&rft.au=BLEIN-NICOLAS,%20Melisande&ALBERTIN,%20Warren&DA%20SILVA,%20Telma&VALOT,%20Benoit&BALLIAU,%20Thierry&rft.genre=article


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