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Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA

dc.rights.licenseopenen_US
dc.relation.isnodoubledb89e9d0-44fb-470b-bd57-d7ba31aa6d0a*
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorZIACH, Krzysztof
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorCHOLLET, Celine
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorPARISSI, Vincent
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorPRABHAKARAN, Panchami
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorCORVAGLIA, Valentina
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBOSE, Partha Pratim
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAXMI-REDDY, Katta
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGODDE, Frederic
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSCHMITTER, Jean-Marie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorCHAIGNEPAIN, Stephane
dc.contributor.authorPOURQUIER, Philippe
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorHUC, Ivan
dc.date.accessioned2020-04-08T07:52:54Z
dc.date.available2020-04-08T07:52:54Z
dc.date.created2018
dc.date.issued2018
dc.identifier.issn1755-4330en_US
dc.identifier.otherhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41557-018-0018-7/MediaObjects/41557_2018_18_MOESM3_ESM.mp4en_US
dc.identifier.otherhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41557-018-0018-7/MediaObjects/41557_2018_18_MOESM1_ESM.pdfen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/4156
dc.description.abstractEnNumerous essential biomolecular processes require the recognition of DNA surface features by proteins. Molecules mimicking these features could potentially act as decoys and interfere with pharmacologically or therapeutically relevant protein-DNA interactions. Although naturally occurring DNA-mimicking proteins have been described, synthetic tunable molecules that mimic the charge surface of double-stranded DNA are not known. Here, we report the design, synthesis and structural characterization of aromatic oligoamides that fold into single helical conformations and display a double helical array of negatively charged residues in positions that match the phosphate moieties in B-DNA. These molecules were able to inhibit several enzymes possessing non-sequence-selective DNA-binding properties, including topoisomerase 1 and HIV-1 integrase, presumably through specific foldamer-protein interactions, whereas sequence-selective enzymes were not inhibited. Such modular and synthetically accessible DNA mimics provide a versatile platform to design novel inhibitors of protein-DNA interactions.
dc.language.isoENen_US
dc.subject.enChemical tools
dc.subject.enDNA-binding proteins
dc.subject.enNucleic acids
dc.title.enSingle helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA
dc.title.alternativeNature Chemen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41557-018-0018-7
dc.subject.halChimie/Matériauxen_US
bordeaux.journalNature Chemistryen_US
bordeaux.page511-518en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.issue5en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03180111
hal.version1
hal.date.transferred2021-03-24T16:36:21Z
hal.exporttrue
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