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Identification of bioactive compounds from Fraxinus angustifolia extracts with anti- NADH oxidase activity of bovine milk xanthine oxidoreductase.

dc.rights.licenseopenen_US
dc.contributor.authorAHMANE, Nadjia
dc.contributor.authorATMANI-KILANI, Dina
dc.contributor.authorCHAHER, Nassima
dc.contributor.authorAYOUNI, Karima
dc.contributor.authorRAHMANI-BERBOUCHA, Meriem
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorDA COSTA, Gregory
dc.contributor.authorDEBBACHE-BENAIDA, Nadjet
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.contributor.authorATMANI, Djebbar
dc.date.accessioned2021-04-23T12:19:00Z
dc.date.available2021-04-23T12:19:00Z
dc.date.issued2019-01-01
dc.identifier.issn1303-6092en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/27076
dc.description.abstractEnFraxinus angustifolia leaves and bark are used in traditional medicine against various inflammatory-related pathologies incumbent to reactive oxygen species (ROS) generation by the NADH oxidase activity of enzymes such as xanthine oxidoreductase (XOR). This study was designed to investigate the in vitro and in vivo inhibitory activities of this enzyme by Fraxinus angustifolia extracts. The leaf organic phase of ethyl acetate (LFA) and its bark aqueous counterpart (BFA) showed the strongest anti-NADH oxidase activity in vitro (IC50 = 38.51 and 42.04 µg mL-1, respectively). They consequently suppressed superoxide generation both enzymatically (53% and 19%, respectively) and nonenzymatically (34% and 19%, respectively). These results were corroborated in vivo, with high antiNADH oxidase potential of the leaves and bark extracts (75.32% and 51.32%, respectively) concomitant with moderate hypouricemic activities (36.84% and 38.59%, respectively). Bio-guided fractionation led to the identification, by LC-DAD-MS/MS, of esculin and calcelarioside in bark and kaempferol glucoside in leaves as the main compounds responsible for the anti-NADH oxidase activity of XOR. These results plead in favor of the use of F. angustifolia as a source of potentially interesting therapeutic substances.
dc.language.isoENen_US
dc.title.enIdentification of bioactive compounds from Fraxinus angustifolia extracts with anti- NADH oxidase activity of bovine milk xanthine oxidoreductase.
dc.title.alternativeTurk J Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3906/biy-1810-26en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed31410081en_US
bordeaux.journalTurkish Journal of Biologyen_US
bordeaux.page133-147en_US
bordeaux.volume43en_US
bordeaux.hal.laboratoriesUnité de Recherche Oenologie - EA 4577en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03206666
hal.version1
hal.date.transferred2021-04-23T12:19:04Z
hal.exporttrue
workflow.import.sourcepubmed
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