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Assessment of Antioxidant Activity and Neuroprotective Capacity on PC12 Cell Line of Frankenia thymifolia and Related Phenolic LC-MS/MS Identification

dc.rights.licenseopenen_US
dc.contributor.authorBEN MANSOUR, Rim
dc.contributor.authorKSOURI, Wided Megdiche
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorCLUZET, Stephanie
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.contributor.authorKSOURI, Riadh
dc.date.accessioned2021-04-19T13:21:26Z
dc.date.available2021-04-19T13:21:26Z
dc.date.issued2016-01-01
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26973
dc.description.abstractEnThis work aimed to investigate the richness of a Tunisian xerohalophyte aerial and root parts on phenolics and to evaluate the antioxidant and neuroprotective properties of this medicinal species. After fractionation using increasing and different solvent polarities, results displayed five fractions, where ethyl acetate (EtOAc) shoot and root fractions possess considerable total phenolic contents (221 and 308 mg of GAE/g of E, resp.) related to their important antioxidant activities such as ORAC (918 and 713 mg of TE/g of E), DPPH (282 and 821 mg of TE/g), and ABTS (778 and 1320 mg of TE/g) tests. Then, the identification of the main compounds by HPLC-DAD-ESI-MS and neuroprotective property of the most active fraction EtOAc were assessed. A total of 14 molecules were identified, which have been described for the first time in . The major compounds identified were pinoresinol and kaempferol glycoside in aerial parts and gallic acid and ellagitannin in roots. Neuroprotective capacity against -amyloid (A) peptide induced toxicity in PC12 cells of EtOAc fraction showed a significant protective activity at lower concentration (25 and 50 M). The relevant antioxidant and neuroprotective activities of EtOAc fraction corroborated their chemical compositions.
dc.language.isoENen_US
dc.title.enAssessment of Antioxidant Activity and Neuroprotective Capacity on PC12 Cell Line of Frankenia thymifolia and Related Phenolic LC-MS/MS Identification
dc.title.alternativeEvid Based Complement Alternat Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1155/2016/2843463en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed27829862en_US
bordeaux.journalEvidence-Based Complementary and Alternative Medicineen_US
bordeaux.page2843463en_US
bordeaux.volume2016en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03202110
hal.version1
hal.date.transferred2021-04-19T13:21:30Z
hal.exporttrue
workflow.import.sourcepubmed
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