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Grapes and their derivatives in modulation of cognitive decline: a critical review of epidemiological and randomized-controlled trials in humans.

dc.rights.licenseopenen_US
dc.contributor.authorRESTANI, Patrizia
dc.contributor.authorFRADERA, Ursula
dc.contributor.authorRUF, Jean-Claude
dc.contributor.authorSTOCKLEY, Creina
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorTEISSEDRE, Pierre Louis
dc.contributor.authorBIELLA, Simone
dc.contributor.authorCOLOMBO, Francesca
dc.contributor.authorLORENZO, Chiara Di
dc.date.accessioned2021-04-13T08:47:23Z
dc.date.available2021-04-13T08:47:23Z
dc.date.issued2021-01-01
dc.identifier.issn1549-7852en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26932
dc.description.abstractEnWith an increase in life expectancy, the incidence of chronic degenerative pathologies such as dementia has progressively risen. Cognitive impairment leads to the gradual loss of skills, which results in substantial personal and financial cost at the individual and societal levels. Grapes and wines are rich in healthy compounds, which may help to maintain homeostasis and reduce the risk of several chronic illnesses, including dementia. This review analyzed papers that were systematically searched in PubMed, MEDLINE, Embase, and CAB-Abstract, using the association between grapes (or their derivatives) and their effects on cognitive functions in humans. Analysis was restricted to epidemiological and randomized-controlled studies. Consumption of grape juice (200-500 mL/day) and/or light-to-moderate wine (one to four glasses/day) was generally associated with improved cognitive performance, while the results for other alcoholic beverages were controversial and inconclusive. Bioactive molecules contained in grapes and wine were also considered, with particular attention paid to resveratrol. Due to the relatively high doses required (150-1000 mg/day) for bioactivity coupled with its low bioavailability, resveratrol is only one of the possible grape-derived compounds that may partly underpin the beneficial effects of grapes on the central nervous system.
dc.language.isoENen_US
dc.subject.enCognition
dc.subject.enCognitive Dysfunction
dc.subject.enHumans
dc.subject.enRandomized Controlled Trials as Topic
dc.subject.enResveratrol
dc.subject.enVitis
dc.subject.enWine
dc.title.enGrapes and their derivatives in modulation of cognitive decline: a critical review of epidemiological and randomized-controlled trials in humans.
dc.title.alternativeCrit Rev Food Sci Nutren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1080/10408398.2020.1740644en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed32208848en_US
bordeaux.journalCritical Reviews in Food Science and Nutritionen_US
bordeaux.page566-576en_US
bordeaux.volume61en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
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