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dc.rights.licenseopenen_US
dc.contributor.authorJOSEFSSON, Emma C
dc.contributor.authorVAINCHENKER, William
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorJAMES, Chloe
dc.date.accessioned2021-03-22T11:12:33Z
dc.date.available2021-03-22T11:12:33Z
dc.date.issued2020-10-14
dc.identifier.issn1422-0067en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26766
dc.description.abstractEnBlood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have also recognised functions in thrombosis, immunity, antimicrobal defense, cancer growth and metastasis, tumour angiogenesis, lymphangiogenesis, inflammatory diseases, wound healing, liver regeneration and neurodegeneration. Their brief life span in circulation is strictly controlled by intrinsic apoptosis, where the prosurvival Bcl-2 family protein, Bcl-xL, has a major role. Blood platelets are produced by large polyploid precursor cells, megakaryocytes, residing mainly in the bone marrow. Together with Mcl-1, Bcl-xL regulates megakaryocyte survival. This review describes megakaryocyte maturation and survival, platelet production, platelet life span and diseases of abnormal platelet number with a focus on the role of Bcl-xL during these processes.
dc.language.isoENen_US
dc.rightsAttribution 3.0 France (CC BY 3.0 FR)
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/fr/
dc.subject.enAnimals
dc.subject.enApoptosis
dc.subject.enBlood Platelet Disorders
dc.subject.enBlood Platelets
dc.subject.enHumans
dc.subject.enMegakaryocytes
dc.subject.enThrombopoiesis
dc.subject.enbcl-X Protein
dc.title.enRegulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases.
dc.title.alternativeInt J Mol Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms21207591en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaireen_US
dc.identifier.pubmed33066573en_US
bordeaux.journalInternational Journal of Molecular Sciencesen_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.issue20en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03176352
hal.version1
hal.date.transferred2021-05-11T09:44:53Z
hal.exporttrue
workflow.import.sourcepubmed
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