JOSEFSSON, Emma C; VAINCHENKER, William; JAMES, Chloe

doi:10.3390/ijms21207591

JAMES, Chloe
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases

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Article de revue

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International Journal of Molecular Sciences. 2020-10-14, vol. 21, n° 20

Resumen en inglés

Blood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have also recognised functions in thrombosis, immunity, antimicrobal defense, cancer growth and metastasis, tumour angiogenesis, lymphangiogenesis, inflammatory diseases, wound healing, liver regeneration and neurodegeneration. Their brief life span in circulation is strictly controlled by intrinsic apoptosis, where the prosurvival Bcl-2 family protein, Bcl-xL, has a major role. Blood platelets are produced by large polyploid precursor cells, megakaryocytes, residing mainly in the bone marrow. Together with Mcl-1, Bcl-xL regulates megakaryocyte survival. This review describes megakaryocyte maturation and survival, platelet production, platelet life span and diseases of abnormal platelet number with a focus on the role of Bcl-xL during these processes.< Leer menos

Palabras clave en inglés

Animals

Apoptosis

Blood Platelet Disorders

Blood Platelets

Humans

Megakaryocytes

Thrombopoiesis

bcl-X Protein

URI

https://oskar-bordeaux.fr/handle/20.500.12278/26766

DOI

http://dx.doi.org/10.3390/ijms21207591

Centros de investigación

Biologie des maladies cardiovasculaires (BMC) - UMR 1034

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Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases.

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Resumen en inglés

Palabras clave en inglés

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Centros de investigación