GONCALVES, A.; BERTRAND, J.; KE, R.; COMETS, E.; DE LAMBALLERIE, X.; MALVY, Denis; PIZZORNO, A.; TERRIER, O.; ROSA CALATRAVA, M.; MENTRE, F.; SMITH, P.; PERELSON, A. S.; GUEDJ, J.

doi:10.1002/psp4.12543

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CPT: Pharmacometrics and Systems Pharmacology. 2020-09, vol. 9, n° 9, p. 509-514

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We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6-87% efficacy. They may help control virus if administered very early, but may not have a major effect in severe patients.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/26734

DOI

http://dx.doi.org/10.1002/psp4.12543

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Bordeaux Population Health Research Center (BPH) - UMR 1219

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Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load

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