BELAROUSSI, Yaniss; ROBLOT, Paul; PEIFFER-SMADJA, N.; DELAYE, T.; MATHOULIN-PELISSIER, Simone; LEMEUX, Joffrey; LE MOAL, G.; CAUMES, E.; ROBLOT, F.; BLEIBTREU, A.

doi:10.3390/jcm9113691

BELAROUSSI, Yaniss
Bordeaux population health [BPH]

ROBLOT, Paul
Bordeaux population health [BPH]

PEIFFER-SMADJA, N.

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Article de revue

Ce document a été publié dans

Journal of Clinical Medicine. 2020-11-17, vol. 9, n° 11

Résumé en anglais

BACKGROUND: During this pandemic situation, some studies have led to hasty conclusions about Corona Virus Disease-19 (COVID-19) treatment, due to a lack of methodology. This pedagogic study aimed to highlight potential biases in research on COVID-19 treatment. METHODS: We evaluate the effect of coffee's active part, 1,3,7-trimethylxanthine (TMX) on patients with COVID-19. A cohort of 93 patients, with a diagnosis of COVID-19 is analyzed. RESULTS: TMX group and control group included, respectively, 26 and 67 patients. In the TMX group, patients had a median length of stay in hospital of 5.5 days shorter than in the control group (9.5 vs. 15 days, p < 0.05). Patients in the control group were more severe than patients in the TMX group with a significantly higher National Early Warning Score 2 (NEWS-2 score) (8 vs. 6, p = 0.002). CONCLUSIONS: Multiple biases prevents us from concluding to an effect of coffee on COVID-19. Despite an important social pressure during this crisis, methodology and conscientiousness are the best way to avoid hasty conclusions that can be deleterious for patients. Identifier: NCT04395742.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/26411

DOI

http://dx.doi.org/10.3390/jcm9113691

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19?

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