POISNEL, G.; ARENAZA-URQUIJO, E.; COLLETTE, F.; KLIMECKI, O. M.; MARCHANT, N. L.; WIRTH, M.; DE LA SAYETTE, V.; RAUCHS, G.; SALMON, E.; VUILLEUMIER, P.; FRISON, Éric; MAILLARD, Aline; VIVIEN, D.; LUTZ, A.; CHETELAT, G.

doi:10.1016/j.trci.2018.10.011

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Alzheimer's & dementia (New York, N. Y.). 2018-12-26, vol. 4, p. 714-723

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Introduction: The Age-Well clinical trial is an ongoing monocentric, randomized, controlled trial aiming to assess an 18-month preventive meditation-based intervention directly targeting the attentional and emotional dimensions of aging to promote mental health and well-being in elderly people. Methods: One hundred thirty-seven cognitively unimpaired older adults are randomized to either an 18-month meditation-based intervention, a structurally matched foreign language training, or a passive control arm. The impact of the intervention and underlying mechanisms are assessed with detailed cognitive, behavioral, biological, neuroimaging and sleep examinations. Results: Recruitment began in late 2016 and ended in May 2018. The interventions are ongoing and will be completed by early 2020. Discussion: This is the first trial addressing the emotional and cognitive dimension of aging with a long-term nonpharmacological approach and using comprehensive assessments to investigate the mechanisms. Results are expected to foster the development of preventive strategies reducing the negative impact of mental conditions and disorders.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/21456

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http://dx.doi.org/10.1016/j.trci.2018.10.011

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Bordeaux Population Health Research Center (BPH) - UMR 1219

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The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults

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