PASIN, Chloe; HALLORAN, M. E.; GILBERT, P. B.; LANGEVIN, E.; OCHIAI, R. L.; PITISUTTITHUM, P.; CAPEDING, M. R.; CARRASQUILLA, G.; FRAGO, C.; CORTES, M.; CHAMBONNEAU, L.; MOODIE, Z.

doi:10.1371/journal.pone.0207878

PASIN, Chloe
Bordeaux population health [BPH]

HALLORAN, M. E.

GILBERT, P. B.

Langue

Article de revue

Ce document a été publié dans

PLoS ONE. 2018, vol. 13, n° 12, p. e0207878

Résumé en anglais

OBJECTIVE: To evaluate the association of rainy season with overall dengue disease incidence and with the efficacy of the Sanofi Pasteur recombinant, live, attenuated, tetravalent vaccine (CYD-TDV) in two randomized, controlled multicenter phase III clinical trials in Asia and Latin America. METHODS: Rainy seasons were defined for each study site using climatological information from the World Meteorological Organization. The dengue attack rate in the placebo group for each study month was calculated as the number of symptomatic, virologically-confirmed dengue events in a given month divided by the number of participants at risk in the same month. Time-dependent Cox proportional hazard models were used to test whether rainy season was associated with dengue disease and whether it modified vaccine efficacy in each of the two trials and in both of the trials combined. FINDINGS: Rainy season, country, and age were all significantly associated with dengue disease in both studies. Vaccine efficacy did not change during the rainy season in any of the analyses. CONCLUSIONS: Although dengue transmission and exposure are expected to increase during the rainy season, our results indicate that CYD-TDV vaccine efficacy remains constant throughout the year in endemic regions.< Réduire

Mots clés en anglais

SISTM

URI

https://oskar-bordeaux.fr/handle/20.500.12278/21439

DOI

http://dx.doi.org/10.1371/journal.pone.0207878

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche