FENG, Xiaoshuang; TATON, Daniel; CHAIKOF, Elliot L.; GNANOU, Yves

doi:10.1021/bm070146r

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

FENG, Xiaoshuang
Laboratoire de Chimie des polymères organiques [LCPO]

TATON, Daniel

Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering

CHAIKOF, Elliot L.
Lab Biomol Mat Res [LBMR]

Langue

Article de revue

Ce document a été publié dans

Biomacromolecules. 2007, vol. 8, n° 8, p. 2374-2378

American Chemical Society

Résumé en anglais

Doubly functionalized dendrimerlike poly(ethylene oxide)s (PEOs) carrying 16 hydroxyl groups at their periphery and one aldehyde group at their focal point were synthesized up to the fourth generation through an iterative divergent approach. First, a protected aldehyde dihydroxyl compound, namely, 3,3-diethoxy-1,2-propanediol, was used as initiator for the anionic ring-opening polymerization (AROP) of ethylene oxide after partial deprotonation (30%) in dimethyl sulfoxide. The two hydroxyls carried by the PEO chain ends of the first generation were subsequently derivatized so as to generate four hydroxyls via a two-step reaction (allylation and osmylation). The next generations of such dendrimerlike PEOs were grown upon repeating the same cycle of AROP and chain-end modification. At the completion of these reactions, the acetal group present at the core was deprotected under acidic conditions to afford the targeted dendrimerlike PEO of fourth generation with a central aldehyde group. The reactivity and accessibility of the latter function was demonstrated upon its conjugation with aniline used as a model compound.< Réduire

Mots clés en anglais

METHODOLOGY

STARS

CHEMISTRY

PEGYLATION

ANIONIC-POLYMERIZATION

DRUG-DELIVERY

POLYMERS

DIEPOXIDES

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Bouquet-type dendrimerlike poly(ethylene oxide)s with a focal aldehyde and peripheral hydroxyls

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Origine

Unités de recherche