BOUSQUET, Antoine; PERRIER-CORNET, Romain; IBARBOURE, Emmanuel; PAPON, Eric; LABRUGÈRE, Christine; HÉROGUEZ, Valérie; RODRIGUEZ-HERNANDEZ, Juan

doi:10.1021/bm8000292

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BOUSQUET, Antoine
Laboratoire de Chimie des polymères organiques [LCPO]

PERRIER-CORNET, Romain
Laboratoire de Chimie des polymères organiques [LCPO]

IBARBOURE, Emmanuel

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Biomacromolecules. 2008, vol. 9, n° 7, p. 1811-1817

American Chemical Society

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In this contribution, the principle of spontaneous surface segregation has been applied for the preparation of polypeptide-functionalized polystyrene microspheres. For that purpose, an amphiphilic diblock copolymer was introduced in the mixture styrene/divinylbenzene and polymerized using AIBN as initiator. During the polymerization, cross-linked particles were obtained in which the diblock copolymer was encapsulated. The amphiphilic diblock copolymers used throughout this study contain a hydrophilic polypeptide segment, either poly(L-lysine) or poly(L-glutamic acid) and a hydrophobic polystyrene block. After 4 h of polymerization, rather monodisperse particles with sizes of ∼3-4 μm were obtained. Upon annealing in hot water, the hydrophilic polypeptides migrate to the interface, hence, either positively charged or neutral particles were obtained when poly(L-lysine) is revealed at the surface and exposed to acidic or basic pH, respectively. On the opposite, negatively charged particles were achieved in basic pH water by using poly(L-glutamic acid) as additive. The surface chemical composition was modified by changing the environment of the particles. Thus, exposure in toluene provoked a surface rearrangement, and due to its affinity, the polystyrene block reorients toward the interface.< Réduire

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Functionalized materials

Polystyrene

Microspheres

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Design of polypeptide-functionalized polystyrene microspheres

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