AGUT, Willy; AGNAOU, Reda; LECOMMANDOUX, Sebastien; TATON, Daniel

doi:10.1002/marc.200800123

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

AGUT, Willy
Laboratoire de Chimie des polymères organiques [LCPO]

AGNAOU, Reda
Laboratoire de Chimie des polymères organiques [LCPO]

LECOMMANDOUX, Sebastien
Laboratoire de Chimie des polymères organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Langue

Article de revue

Ce document a été publié dans

Macromolecular Rapid Communications. 2008, vol. 29, n° 12-13, p. 1147-1155

Wiley-VCH Verlag

Résumé en anglais

A novel synthetic methodology to diblock copolypeptides was developed by ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs) from alpha-omega-functionalized initiators combined with the Huisgen 1,3 dipolar cycloaddition (click chemistry). Poly(gamma-benzyl-L-glutamate) (PBLGlu) and poly(trifluoroacetyl-L-Lysine) (PTFALys) containing either an azide or an alkyne functional group in alpha-position were first synthesized by ROP of the corresponding NCA at room temperature in DMF as a solvent, using appropriate omega-amino-containing alpha-alkyne and a-azido difunctional initiators. The Copper(I) -catalyzed coupling reactions of alpha-azido-PBLGlu with the alpha-alkyne-PTFALys, on the one hand, and of the alpha-alkyne-PBLGlu with the alpha-azido-PTFALys, on the other hand were suitably accomplished in DMF. This afforded the targeted PBLGlu-b-PTFALys diblock copolypeptides pos- sessing a triazole group in between the two 1 blocks, as evidenced by SEC, IR, and NMR analysis. Block copolypeptides could be successfully purified by selective extraction with chloroform.< Réduire

Mots clés en anglais

L-LYSINE

L-LEUCINE

MODULAR SYNTHESIS

ONE-POT SYNTHESIS

L-GLUTAMIC ACID

ROD-COIL

TRIBLOCK COPOLYMERS

DIBLOCK COPOLYMERS

MATERIALS SCIENCE

POLYPEPTIDE

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Synthesis of block copolypeptides by click chemistry

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Origine

Unités de recherche