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Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors.

dc.rights.licenseopenen_US
dc.contributor.authorRALPH DE OLIVEIRA, Isabella Luiza
dc.contributor.authorDA SILVA MOURA, José Arion
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorRECORDON-PINSON, Patricia
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorLAGADEC, Floriane
dc.contributor.authorDA ROSA, Michelle Melgarejo
dc.contributor.authorGONÇALVES, Sayonara Maria Calado
dc.contributor.authorVIANA, Douglas Carvalho Francisco
dc.contributor.authorDE MORAES GOMES, Paulo André Teixeira
dc.contributor.authorDA ROCHA PITTA, Marina Galdino
dc.contributor.authorDE MELO RÊGO, Moacyr Jesus Barreto
dc.contributor.authorPEREIRA, Michelly Cristiny
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorMÉTIFIOT, Mathieu
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorANDREOLA, Marie-Line
dc.contributor.authorDA ROCHA PITTA, Maira Galdino
dc.date.accessioned2025-09-29T10:45:22Z
dc.date.available2025-09-29T10:45:22Z
dc.date.issued2025-08-22
dc.identifier.issn2076-2607en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207680
dc.description.abstractEnZika virus (ZIKV) remains a pressing global health concern due to its association with congenital Zika syndrome and the current lack of approved antiviral therapies. In this study, we evaluated the antiviral activity of three novel thiazolidinedione derivatives, GQ-402, GQ-396, and ZKC-10, against ZIKV in vitro and investigated their potential molecular targets through in silico analysis. GQ-402 exhibited the highest antiviral potency, with an IC of 15.7 µM, while ZKC-10 achieved the most substantial reduction in viral RNA levels, as determined by RT-qPCR. Molecular docking studies identified GQ-396 as the top-ranked inhibitor of the NS2B-NS3 protease and NS5 RNA-dependent RNA polymerase, suggesting distinct mechanisms of action among the compounds. These findings highlight the therapeutic potential of thiazolidinedione derivatives and underscore the need for further investigation to develop effective treatments for ZIKV infection.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enNovel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors.
dc.title.alternativeMicroorganismsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/microorganisms13091967en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed41011300en_US
bordeaux.journalMicroorganismsen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue9en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-05288475
hal.version1
hal.date.transferred2025-09-29T10:45:26Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Microorganisms&rft.date=2025-08-22&rft.volume=13&rft.issue=9&rft.eissn=2076-2607&rft.issn=2076-2607&rft.au=RALPH%20DE%20OLIVEIRA,%20Isabella%20Luiza&DA%20SILVA%20MOURA,%20Jos%C3%A9%20Arion&RECORDON-PINSON,%20Patricia&LAGADEC,%20Floriane&DA%20ROSA,%20Michelle%20Mel&rft.genre=article


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